Mattsson L A, Samsioe G
Acta Obstet Gynecol Scand Suppl. 1985;130:53-8. doi: 10.3109/00016348509157148.
Twenty-six peri- and postmenopausal women were treated with daily dose of 2 mg 17-beta-estradiol, 1 mg estriol and 1 mg norethisterone-acetate in a continuous regimen for 12 months. Clinical parameters such as vasomotor symptoms, bleeding patterns and histopathology were recorded. Blood samples were collected before, after 3 months and after 12 months of treatment and were analysed for estradiol-17-beta, estrone, androstenedione in serum and lipoprotein lipids. A marked reduction of hot flushes and sweatings was noted and the number of days with bleeding gradually decreased during treatment, especially in the postmenopausal group of women. No signs of hyperplasia of the endometrium were recorded. A decrease in the serum concentration of testosterone and androstenedione was found during treatment. The reduction in triglycerides in very low density lipoproteins after 3 months, concomitant with a decrease in the cholesterol content of high density lipoproteins, was interpreted as an effect mainly of the progestogen component in the preparation. The present formulation of estrogen-progestogen, continuously administered, may be an appropriate alternative treatment regimen for many women. One proposition of how to treat women with climacteric complaints around the menopause is presented.
26名围绝经期和绝经后女性采用连续用药方案，每日服用2毫克17-β-雌二醇、1毫克雌三醇和1毫克醋酸炔诺酮，为期12个月。记录血管舒缩症状、出血模式和组织病理学等临床参数。在治疗前、治疗3个月后和12个月后采集血样，分析血清中17-β-雌二醇、雌酮、雄烯二酮以及脂蛋白脂质。潮热和出汗明显减少，治疗期间出血天数逐渐减少，尤其是绝经后女性组。未记录到子宫内膜增生迹象。治疗期间发现血清睾酮和雄烯二酮浓度降低。3个月后极低密度脂蛋白中的甘油三酯减少，同时高密度脂蛋白中的胆固醇含量降低，这主要被解释为制剂中孕激素成分的作用。目前连续给药的雌激素-孕激素制剂可能是许多女性合适的替代治疗方案。本文提出了一种治疗绝经前后有更年期症状女性的建议。
