基于广角扫频源光学相干断层扫描血管造影术测量的平均小动脉直径：平均动脉压的高敏指标
Mean Arteriolar Diameter Measured from Wide-Field Swept-Source OCT Angiography: A Highly Sensitive Indicator for Mean Arterial Pressure.
作者信息
Li Yuchen, Qu Yuyao, Zhang Hanze, Bian Yue, Yuan Langxuan, Hu Jingbo, Xu Shengrui, Xu Xiayu, Lei Jianqin
机构信息
Department of Ophthalmology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, PR China.
出版信息
Ophthalmol Sci. 2024 Dec 17;5(3):100679. doi: 10.1016/j.xops.2024.100679. eCollection 2025 May-Jun.
PURPOSE
To investigate the metrics of retinal arterioles and venules based on the en face images of the superficial retina using wide-field swept-source OCT angiography (SSOCTA) and assess their relationships with specific systemic parameters in a normal sample.
DESIGN
Cross-sectional study.
PARTICIPANTS
Normal volunteers with no history of hypertension, diabetes, or significant eye diseases were recruited at the outpatient clinic of the First Affiliated Hospital of Xi'an Jiaotong University. Eligible eyes had a corrected visual acuity of 20/25 or better and an intraocular pressure (IOP) not exceeding 21 mmHg.
METHODS
The SSOCTA scans of 24 × 20 mm in size were acquired from both eyes of each participant, along with measurements of axial length (AL), IOP, real-time mean arterial pressure (MAP), and body mass index (BMI). Retinal arterioles and venules were manually segmented and distinguished from the disc margin to their capillary junctions in the superficial retinal layer. Image processing and calculations were performed using ImageJ.
MAIN OUTCOME MEASUREMENTS
The averaged caliber and fractal dimension of arteries and veins, as well as the arteriovenous ratio, were calculated from binarized vascular images. Generalized linear mixed models were used to test correlations between systemic parameters and these metrics.
RESULTS
A total of 54 eyes from 44 participants were included after screening. Univariate analysis revealed a significant negative impact of MAP on averaged caliber of retinal artery (B = -0.003, = 0.004) and averaged caliber of retinal vein (ACvein) (B = -0.002, = 0.045), whereas age, sex, BMI, AL, and IOP showed no significant impact on these metrics. Variations among graders significantly influenced most metrics; however, real-time MAP continued to predict retinal arteriolar caliber after adjusting for graders (B = -0.002, = 0.03).
CONCLUSIONS
The mean arteriolar diameter measured using wide-field SSOCTA could serve as a highly sensitive indicator of systemic vascular changes.
FINANCIAL DISCLOSURES
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
目的
使用超广角扫频源光学相干断层扫描血管造影（SSOCTA），基于视网膜浅层的正面图像研究视网膜小动脉和小静脉的测量指标，并评估其与正常样本中特定全身参数的关系。
设计
横断面研究。
参与者
在西安交通大学第一附属医院门诊招募无高血压、糖尿病或重大眼部疾病史的正常志愿者。符合条件的眼睛矫正视力为20/25或更好，眼压（IOP）不超过21 mmHg。
方法
从每位参与者的双眼获取大小为24×20 mm的SSOCTA扫描图像，同时测量眼轴长度（AL）、眼压、实时平均动脉压（MAP）和体重指数（BMI）。在视网膜浅层从视盘边缘到其毛细血管连接处手动分割并区分视网膜小动脉和小静脉。使用ImageJ进行图像处理和计算。
主要观察指标
从二值化血管图像计算动脉和静脉的平均管径、分形维数以及动静脉比。使用广义线性混合模型测试全身参数与这些测量指标之间的相关性。
结果
筛选后共纳入44名参与者的54只眼睛。单因素分析显示，MAP对视网膜动脉平均管径（B = -0.003，P = 0.004）和视网膜静脉平均管径（ACvein）（B = -0.002，P = 0.045）有显著负面影响，而年龄、性别、BMI、AL和眼压对这些测量指标无显著影响。分级者之间的差异对大多数测量指标有显著影响；然而，在调整分级者因素后，实时MAP仍可预测视网膜小动脉管径（B = -0.002，P = 0.03）。
结论
使用超广角SSOCTA测量的平均小动脉直径可作为全身血管变化的高度敏感指标。
财务披露
在本文末尾的脚注和披露中可能会发现专有或商业披露信息。
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