Department of Cardiology, Academic Hospital Paramaribo, Paramaribo, Suriname.
Department of Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
J Hum Hypertens. 2020 Feb;34(2):108-116. doi: 10.1038/s41371-018-0144-0. Epub 2018 Dec 19.
Aortic pulse wave velocity has emerged as an important predictor of cardiovascular events, but data on ethnic differences in pulse wave velocity remain scarce. We explored differences in pulse wave velocity between people of Asian and African ancestry. Data were used from the cross-sectional Healthy Life in Suriname (HELISUR) study. Pulse wave velocity was estimated oscillometrically with the Arteriograph. We included 353 Asians and 364 Africans, aged respectively 44.9 (SD 13.5) and 42.8 (SD 14.1) years (p = 0.05). Crude median PWV was higher in Asians than in Africans (8.1 [IQR 6.9-10.1] m/s vs. 7.7 [IQR 6.5-9.3] m/s, p = 0.03), which was mainly attributable to an increased PWV in Asians ≥ 50 years (10.1 [IQR 8.7-11.8] m/s vs. 9.1 [IQR 7.9-11.3] m/s in Africans ≥50 years, p < 0.01). After adjustment for age and MAP in multivariable linear regression, Asians had a 1.044 [95% CI 1.019-1.072] m/s higher PWV compared to Africans. Additional adjustment for sex, glucose, total cholesterol, HDL cholesterol, triglycerides, BMI, and waist circumference did not substantially change the difference in pulse wave velocity between Asians and Africans (+1.044 [95% CI 1.016-1.074] m/s for Asians vs. Africans). In conclusion, persons of Asian ancestry have a higher pulse wave velocity than those of African ancestry. This persisted after adjustment for important cardiovascular risk parameters, including age and blood pressure. The higher PWV found in Asians could be consistent with their increased coronary heart disease risk.
脉搏波速度已成为心血管事件的重要预测指标，但有关脉搏波速度在不同种族之间差异的数据仍然很少。我们探讨了亚洲人和非洲人后裔之间脉搏波速度的差异。本研究数据来自横断面苏里南健康生活研究（HELISUR）。脉搏波速度使用动脉脉搏描记仪进行示波法测量。我们纳入了 353 名亚洲人和 364 名非洲人，年龄分别为 44.9（SD 13.5）岁和 42.8（SD 14.1）岁（p=0.05）。亚洲人的脉搏波速度中位数高于非洲人（8.1[IQR 6.9-10.1]m/s 比 7.7[IQR 6.5-9.3]m/s，p=0.03），这主要归因于亚洲人≥50 岁者的脉搏波速度增加（10.1[IQR 8.7-11.8]m/s 比非洲人≥50 岁者的 9.1[IQR 7.9-11.3]m/s，p<0.01）。在多变量线性回归中，经年龄和平均动脉压校正后，亚洲人的脉搏波速度比非洲人高 1.044[95%CI 1.019-1.072]m/s。进一步校正性别、血糖、总胆固醇、高密度脂蛋白胆固醇、甘油三酯、BMI 和腰围后，亚洲人和非洲人之间的脉搏波速度差异没有实质性变化（亚洲人比非洲人高 1.044[95%CI 1.016-1.074]m/s）。总之，亚洲人后裔的脉搏波速度高于非洲人后裔。在调整重要心血管风险参数（包括年龄和血压）后，这种差异仍然存在。亚洲人较高的脉搏波速度可能与他们增加的冠心病风险一致。
