Magalhães Pedro, Capingana Daniel P, Silva Amílcar B T, Ferreira Albano V L, de Sá Cunha Roberto, Rodrigues Sérgio L, Mill José G
Federal University of Espírito Santo, Vitoria, Brazil,
Age (Dordr). 2013 Dec;35(6):2345-55. doi: 10.1007/s11357-012-9504-9. Epub 2013 Jan 15.
Pulse wave velocity (PWV) is an independent predictor of cardiovascular (CV) risk. Higher PWV values have been observed in Africans; however, there are no established age- and gender-adjusted reference values for this population. Therefore, PWV was measured using a validated device (Complior SP) in 544 subjects recruited from an occupational cohort of employees of a public university in Angola. Since high blood pressure (BP) is an important factor influencing PWV, a subsample of 301 normotensive subjects (aged 22-72 years) was selected for this study. A subset of 131 individuals without CV risk factors was considered the healthy group (HG), while the entire group (n = 301) comprised the less healthy group (LHG). Predictors of PWV were evaluated using multiple regression analyses and age- and gender-specific percentile tables and curves were constructed. Age and PWV means were 36 ± 9.7 years and 6.6 ± 1.0 m/s in the HG, respectively, and 39.9 ± 10.2 years and 7.3 ± 1.3 m/s in the LHG. Age and plasma uric acid (UA) were the only significant PWV predictors in the HG, while age, mean BP (MBP), and gender showed significant prediction of PWV in the multiple regression analysis in the LHG. Age- and gender-adjusted reference values of PWV were provided for healthy and less healthy normotensive Africans. Considering the small sample size of our cohort, these preliminary results should be used cautiously until data on robust sample of the general population can be obtained.
脉搏波速度（PWV）是心血管（CV）风险的独立预测指标。在非洲人中观察到较高的PWV值；然而，该人群尚无既定的年龄和性别调整参考值。因此，使用经过验证的设备（Complior SP）对从安哥拉一所公立大学员工职业队列中招募的544名受试者进行了PWV测量。由于高血压（BP）是影响PWV的重要因素，本研究选取了301名血压正常的受试者（年龄22 - 72岁）作为子样本。131名无心血管危险因素的个体子集被视为健康组（HG），而整个组（n = 301）构成健康状况较差组（LHG）。使用多元回归分析评估PWV的预测因素，并构建年龄和性别特异性百分位数表及曲线。HG组的年龄和PWV均值分别为36±9.7岁和6.6±1.0米/秒，LHG组分别为39.9±10.2岁和7.3±1.3米/秒。年龄和血浆尿酸（UA）是HG组中仅有的显著PWV预测因素，而在LHG组的多元回归分析中，年龄、平均血压（MBP）和性别对PWV有显著预测作用。提供了健康和健康状况较差的血压正常非洲人的年龄和性别调整后的PWV参考值。考虑到我们队列的样本量较小，在获得关于一般人群的可靠样本数据之前，应谨慎使用这些初步结果。
