Qi Peiyao, Fu Xiaomin, Zhao Dan, Li Chunlin, Lu Yanhui, Li Nan
Department of Endocrinology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Clinics of Cadre, Department of Outpatient, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Front Nutr. 2024 Aug 23;11:1450265. doi: 10.3389/fnut.2024.1450265. eCollection 2024.
The aim of this study is to investigate the impact of vitamin D supplementation on the muscle strength of the elderly.
This retrospective, propensity score-matched study included 160 middle-aged and elderly individuals from a community in Beijing, China. The control group (n=110) received health education and lifestyle guidance, while the intervention group (n=50) was given oral vitamin D supplementation in addition to health education and lifestyle guidance. All participants underwent laboratory tests, muscle function, and physical function at baseline and follow-up.
In the propensity score-matched cohort of 41 patients per group, the levels of serum calcium and 25-hydroxyvitamin D in both groups were improved significantly by the end of the study (<0.05), with the intervention group showing a more significant improvement. The muscle strength of the left lower limb in the intervention group significantly increased after the intervention (<0.05). The results also showed that the grip strength and pinch strength of the patients in both groups increased after the intervention, and the difference between the two groups was statistically significant (<0.05).
The findings of this study suggest that vitamin D supplementation, in conjunction with lifestyle guidance and health education, is beneficial for enhancing the upper and lower limb strength of patients.
本研究旨在探讨补充维生素D对老年人肌肉力量的影响。
这项回顾性、倾向评分匹配研究纳入了来自中国北京一个社区的160名中老年人。对照组（n = 110）接受健康教育和生活方式指导，而干预组（n = 50）除接受健康教育和生活方式指导外，还给予口服维生素D补充剂。所有参与者在基线和随访时均接受实验室检查、肌肉功能和身体功能评估。
在每组41例患者的倾向评分匹配队列中，到研究结束时，两组的血清钙和25-羟基维生素D水平均显著改善（<0.05），干预组改善更为显著。干预后，干预组左下肢肌肉力量显著增加（<0.05）。结果还显示，两组患者干预后的握力和捏力均增加，两组之间的差异具有统计学意义（<0.05）。
本研究结果表明，补充维生素D，结合生活方式指导和健康教育，有利于增强患者的上下肢力量。
