Kalogeropoulos N K, Whitehead R
Department of Pathology, Flinders Medical Centre, Bedford Park, South Australia.
J Clin Pathol. 1988 Oct;41(10):1093-8. doi: 10.1136/jcp.41.10.1093.
Campylobacter-like organisms were detected by light microscopy in association with 57 of 102 (56%) of gastric ulcers, all the gastric erosions associated with gastritis, three of five (60%) of gastric erosions without gastritis, five of 13 (39%) of mild superficial gastritis and two of 36 (6%) of normal gastric mucosa. They were also seen in four of 20 (20%) of duodenal ulcers, but not in duodenal erosions with duodenitis or normal duodenal biopsy specimens. They were seen in association with 12 of 64 (19%) of cases of Barrett's oesophagus. Moniliasis was seen in nine of 78 (12%) of the gastric ulcers in which campylobacter-like organisms were found, and the incidence of moniliasis was three of 15 (20%) in association with duodenal ulcers when ulcer debris was present in biopsy material, and in association with six of 25 (24%) of cases of Barrett's oesophagus. These findings do not support the hypothesis that campylobacter-like organisms cause inflammatory and ulcerative lesions of the upper gastrointestinal tract.
通过光学显微镜检查发现，在102例胃溃疡中有57例（56%）、所有与胃炎相关的胃糜烂、5例无胃炎的胃糜烂中的3例（60%）、13例轻度浅表性胃炎中的5例（39%）以及36例正常胃黏膜中的2例（6%）中存在类弯曲杆菌生物。在20例十二指肠溃疡中有4例（20%）发现了它们，但在伴有十二指肠炎的十二指肠糜烂或正常十二指肠活检标本中未发现。在64例巴雷特食管病例中有12例（19%）发现了它们。在发现类弯曲杆菌生物的78例胃溃疡中有9例（12%）出现念珠菌病，当活检材料中存在溃疡碎片时，十二指肠溃疡患者中念珠菌病的发生率为15例中的3例（20%），在巴雷特食管病例中有25例中的6例（24%）出现念珠菌病。这些发现不支持类弯曲杆菌生物导致上消化道炎症和溃疡性病变的假说。
