a State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering , Nanjing Tech University , Nanjing , China.
b Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) , Nanjing Tech University , Nanjing , China.
Crit Rev Biotechnol. 2019 Mar;39(2):235-248. doi: 10.1080/07388551.2018.1530634. Epub 2018 Dec 20.
2-Phenylethanol (2-PE), an important flavor and fragrance compound with a rose-like smell has been widely used in the cosmetics, perfume, and food industries. Traditional production of 2-PE was mainly through the extraction from plant materials or by chemical synthesis. However, the increasing demand of consumers for natural flavors cannot be met by these methods. Biological production of 2-PE has emerged to be an appealing solution due to an environmental friendly process and the definition of a "natural" product. In this review, we have comprehensively summarized the current status and perspectives for biological 2-PE production in terms of its advantages over classical chemical synthesis and extraction from natural plants. A comprehensive description of 2-PE synthetic pathways and global regulation mechanisms, strategies to increase 2-PE production, and the utilization of agro-industrial wastes as feedstocks has been systematically discussed. Furthermore, the application of in situ product removal techniques have also been highlighted.
2-苯乙醇（2-PE）是一种具有玫瑰香味的重要风味和香料化合物，已广泛应用于化妆品、香水和食品行业。传统的 2-PE 生产主要通过从植物材料中提取或通过化学合成。然而，消费者对天然香料的需求不断增加，这些方法无法满足。由于环保工艺和“天然”产品的定义，生物生产 2-PE 已成为一种有吸引力的解决方案。在本文中，我们全面总结了生物法生产 2-PE 的现状和展望，包括其相对于经典化学合成和从天然植物中提取的优势。我们系统地讨论了 2-PE 的合成途径和全局调控机制、提高 2-PE 产量的策略以及利用农业工业废物作为原料的情况。此外，还强调了原位产物去除技术的应用。
