Swiecicki Paul L, Brennan Julia R, Mierzwa Michelle, Spector Matthew E, Brenner J Chad
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan, U.S.A.
Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, U.S.A.
Laryngoscope. 2019 Aug;129(8):1836-1843. doi: 10.1002/lary.27725. Epub 2018 Dec 20.
Head and neck squamous cell carcinomas are aggressive tumors that often present at advanced stage in difficult-to-biopsy regions of the head and neck. With the rapid move to analyze circulating tumor DNA (ctDNA) to either detect cancer or monitor disease progression and response to therapy, we have designed this article as a primer to understand the recent studies that support a transition to use these circulating biomarkers as a part of routine clinical care. Whereas some technical challenges still need to be overcome, the utility of ctDNA in cancer care is already evident from these early studies. Therefore, it is critical to understand recent advances in this area as well as emerging questions that need to be addressed as these biomarkers move closer to enhancing routine clinical care paradigms. Laryngoscope, 129:1836-1843, 2019.
头颈部鳞状细胞癌是侵袭性肿瘤，常在头颈部难以活检的区域处于晚期时出现。随着迅速转向分析循环肿瘤DNA（ctDNA）以检测癌症或监测疾病进展及对治疗的反应，我们撰写本文作为入门读物，以了解支持将这些循环生物标志物作为常规临床护理一部分的最新研究。尽管仍需克服一些技术挑战，但从这些早期研究中ctDNA在癌症护理中的效用已很明显。因此，了解该领域的最新进展以及随着这些生物标志物更接近改善常规临床护理模式而出现的需要解决的新问题至关重要。《喉镜》，2019年，第129卷：1836 - 1843页。
