Krieglstein G K, Leydhecker W
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Feb 22;205(3):141-6. doi: 10.1007/BF00414393.
The intraocular pressure responses of topically applied dipivalyl epinephrine (DPE: 0.025, 0.1, and 0.25%) were investigated in three series of open angle glaucoma patients in a double blind study. IOP responses were compared intra-individually with the effects of 1% epinephrine hydrochloride. 0.1% DPE gave an IOP reduction similar to that of 1% epinephrine-HCl. The change in IOP was less with 0.025% DPE and statistically significantly greater with 0.25% DPE when compared with the conventional epinephrine preparation. The clinical advantages of the 'pro drug' DPE are pointed out.
在一项双盲研究中，对三组开角型青光眼患者局部应用二特戊酰肾上腺素（DPE：0.025%、0.1%和0.25%）后的眼压反应进行了研究。将眼压反应在个体内与1%盐酸肾上腺素的作用进行比较。0.1% DPE降低眼压的效果与1%盐酸肾上腺素相似。与传统肾上腺素制剂相比，0.025% DPE引起的眼压变化较小，而0.25% DPE引起的眼压变化在统计学上显著更大。文中指出了“前药”DPE的临床优势。
