Ahuja H G, Cline M J
Med Oncol Tumor Pharmacother. 1988;5(4):211-22. doi: 10.1007/BF03003187.
In recent years, a number of non-random chromosomal alterations have been identified in specific populations of acute lymphoblastic leukemic cells of either B-cell or T-cell lineage. The most frequently involved chromosomal sites are 1q, 4q, 6q, 7q, 8q, 9p, 9q, 10q, 11p, 12p, 14q, 19p and 22q. Genes located near frequent breakpoints include c-myc, c-abl and the genes for the T-cell alpha and beta receptors. In addition, approximately 20 other genes potentially involved in the leukemic process are located near less frequently encountered, but consistent, chromosomal breakpoints.
近年来，在B细胞或T细胞系急性淋巴细胞白血病细胞的特定群体中，已鉴定出一些非随机染色体改变。最常涉及的染色体位点是1q、4q、6q、7q、8q、9p、9q、10q、11p、12p、14q、19p和22q。位于常见断点附近的基因包括c-myc、c-abl以及T细胞α和β受体的基因。此外，大约20个其他可能参与白血病过程的基因位于较少见但一致的染色体断点附近。
