Chan-Yeung M, Ashley M J, Corey P, Maledy H
Am Rev Respir Dis. 1978 Feb;117(2):239-45. doi: 10.1164/arrd.1978.117.2.239.
Epidemiologic surveys were carried out on 1,138 white men employed in sawmills and grain elevator terminals in British Columbia. In addition to the administration of an occupational-health questionnaire and spirometry, Pi phenotype and the concentration of serum alpha1-antitrypsin were determined. Most of the workers (88.8 per cent) had the Pi M phenotype, whereas 8.0 per cent had the MS phenotype, and 2.7 per cent had the MZ phenotype. Very few workers (0.4 per cent) had other phenotypes. No differences were found among the 3 major phenotypes in the prevalence of chest symptoms and lung function abnormalities, even among cigarette smokers. These findings did not indicate that workers have the MZ phenotype with intermediate alpha-1-antitrypsin deficiency are particularly susceptible to the development of chronic obstructive lung disease under the conditions prevailing in these industries.
对不列颠哥伦比亚省锯木厂和谷物升降梯码头的1138名白人男性进行了流行病学调查。除了进行职业健康问卷调查和肺活量测定外，还测定了Pi表型和血清α1 -抗胰蛋白酶浓度。大多数工人（88.8%）具有Pi M表型，而8.0%具有MS表型，2.7%具有MZ表型。极少数工人（0.4%）具有其他表型。在胸部症状患病率和肺功能异常方面，即使在吸烟者中，3种主要表型之间也未发现差异。这些发现并未表明，在这些行业普遍存在的条件下，具有α1 -抗胰蛋白酶中度缺乏的MZ表型工人特别易患慢性阻塞性肺病。
