Song Jiajia, Yang Ruilin, Yang Jing, Zhou Lufang
Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education, Tianjin University, Tianjin, China.
Front Physiol. 2018 Dec 6;9:1670. doi: 10.3389/fphys.2018.01670. eCollection 2018.
There is increasing evidence that diabetic cardiomyopathy increases the risk of cardiac arrhythmia and sudden cardiac death. While the detailed mechanisms remain incompletely understood, the loss of mitochondrial function, which is often observed in the heart of patients with diabetes, has emerged as a key contributor to the arrhythmogenic substrates. In this mini review, the pathophysiology of mitochondrial dysfunction in diabetes mellitus is explored in detail, followed by descriptions of several mechanisms potentially linking mitochondria to arrhythmogenesis in the context of diabetic cardiomyopathy.
越来越多的证据表明，糖尿病性心肌病会增加心律失常和心源性猝死的风险。虽然具体机制仍未完全明确，但线粒体功能丧失已成为致心律失常基质的关键因素，这种情况在糖尿病患者的心脏中经常出现。在这篇小型综述中，我们详细探讨了糖尿病中线粒体功能障碍的病理生理学，随后描述了在糖尿病性心肌病背景下，线粒体与心律失常发生潜在相关的几种机制。
