Rush Amanda, Matzke Lise, Cooper Simon, Gedye Craig, Byrne Jennifer A, Watson Peter H
1 Children's Cancer Research Unit, Kids Research, The Children's Hospital at Westmead, Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
2 Office of Biobank Education and Research, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
Biopreserv Biobank. 2019 Jun;17(3):219-229. doi: 10.1089/bio.2018.0099. Epub 2018 Dec 21.
Tumor biobanks have become critical components of the cancer research infrastructure. Consideration of how to place appropriate values on tumor biobanks is important for all stakeholders. At the level of individual biobanks, value is important in determining how to contribute to, utilize, and fund biobanks. At the level of the research system, value is important in determining how to evaluate, rationalize, and sustain or modify the investments in this infrastructure. This review considers approaches and indicators for evaluation of a biobank with a particular focus on utilization, as one important indicator of value, from the perspective of the researcher and funder. The patterns of utilization and the influence of different phases and approaches of research, and types of biobank are described, as well as strategies for biobanks to increase utilization and therefore their value to research.
肿瘤生物样本库已成为癌症研究基础设施的关键组成部分。考虑如何为肿瘤生物样本库赋予适当价值对所有利益相关者而言都很重要。在单个生物样本库层面，价值对于确定如何为生物样本库做出贡献、加以利用以及提供资金支持至关重要。在研究系统层面，价值对于确定如何评估、合理化以及维持或调整对这一基础设施的投资很重要。本综述从研究者和资助者的角度，探讨了评估生物样本库的方法和指标，特别关注作为价值重要指标之一的利用率。文中描述了利用模式、研究不同阶段和方法以及生物样本库类型的影响，还介绍了生物样本库提高利用率从而提升其研究价值的策略。
