用于癌症生物标志物研究的生物样本库：问题与解决方案

Matzke Lise A, Watson Peter H

Office of Biobank Education and Research, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Biobanking and Biospecimen Research Services, Deeley Research Centre, BC Cancer Agency, Victoria, British Columbia, Canada.

Biomark Insights. 2020 Oct 19;15:1177271920965522. doi: 10.1177/1177271920965522. eCollection 2020.

Biomarkers are critical tools that underpin precision medicine. However there has been slow progress and frequent failure of biomarker development. The root causes are multifactorial. Here, we focus on the need for fast, efficient, and reliable access to quality biospecimens as a critical area that impacts biomarker development. We discuss the past history of biobanking and the evolution of biobanking processes relevant to the specific area of cancer biomarker development as an example, and describe some solutions that can improve this area, thus potentially accelerating biomarker research.

生物标志物是精准医学的关键工具。然而，生物标志物的开发进展缓慢且频繁失败。其根本原因是多方面的。在此，我们将重点关注快速、高效且可靠地获取优质生物样本的必要性，这是影响生物标志物开发的一个关键领域。我们以生物样本库的历史以及与癌症生物标志物开发特定领域相关的生物样本库流程的演变为例进行讨论，并描述一些可改善该领域的解决方案，从而有可能加速生物标志物研究。