Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt.
Animal Production Department, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt.
Biomed Pharmacother. 2019 Mar;111:42-50. doi: 10.1016/j.biopha.2018.12.069. Epub 2018 Dec 18.
Cancer is an everyday medical concern which requires an appropriate treatment strategy. The malfunction of cell cycle is a well-established cause for cancer induction. Chemotherapy and radiation are the standard available therapeutic approach for cancer treatment; however severe side effects were reported in association to such treatments, for instance, the efficacy of patients' immune system is adversely affected in apart by radiation. These side effects may be minimized by providing novel remedial preparations. Complementary and alternative medicinal compounds, which were obtained from fresh or marine flora particularly micro and macro algae, were reported to its anti-cancerous activities. Several types of bioactive molecules are also present in microalgae, such as carotenoids, various forms of polysaccharides, vitamins, sterol, fibres, minerals…ect; the great unused biomass of microalgae and their excellent diversity of chemical constituents may introduce a major step in developing of anti-malignant drugs. Previously, such characteristic of microalgal bio-diversity was commercially exploited to make food supplements and gelling substances. However, recently, several investigations were designed to study the potential anti-carcinogenic effect of microalgal extracts, where they mostly concluded their ability to induce apoptotic cancer cell death via caspase dependent or independent pathways. In this review paper, we reported the various species of microalgae that possessed anti-tumor activity, the tumor cell lines altered through using microalgal extracts along with the levels of such extracts that reported to its inhibitor effect against cell cycle and proliferation.
癌症是一种常见的医学关注点，需要制定适当的治疗策略。细胞周期功能障碍是癌症发生的一个既定原因。化疗和放疗是癌症治疗的标准治疗方法；然而，这些治疗方法会产生严重的副作用，例如，辐射会对患者的免疫系统产生不利影响。通过提供新的治疗制剂可以最小化这些副作用。从新鲜或海洋植物中获得的补充和替代医学化合物，特别是微藻和巨藻，被报道具有抗癌活性。微藻中也存在几种类型的生物活性分子，如类胡萝卜素、各种形式的多糖、维生素、固醇、纤维、矿物质……等；微藻巨大的未利用生物质及其出色的化学成分多样性可能为开发抗恶性药物带来重大进展。此前，这种微藻生物多样性的特征已被商业利用来制造食品补充剂和凝胶物质。然而，最近，设计了几项研究来研究微藻提取物的潜在抗癌作用，这些研究大多得出结论，微藻提取物通过 caspase 依赖或非依赖途径诱导癌细胞凋亡死亡。在这篇综述文章中，我们报告了具有抗肿瘤活性的各种微藻物种，以及通过使用微藻提取物改变的肿瘤细胞系，以及报告的对细胞周期和增殖有抑制作用的此类提取物的水平。
