Sfakianoudis Konstantinos, Simopoulou Mara, Nitsos Nikolaos, Rapani Anna, Pappas Athanasios, Pantou Agni, Chronopoulou Margarita, Deligeoroglou Efthymios, Koutsilieris Michael, Pantos Konstantinos
Centre for Human Reproduction, Genesis Athens Clinic, 14-16, Papanikoli, 15232 Athens, Greece.
Department of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, Greece.
J Clin Med. 2018 Dec 20;8(1):1. doi: 10.3390/jcm8010001.
This report presents the case of a woman aged 40 who has experienced premature menopause from the age of 35. Having rejected oocyte donation, she opted for intraovarian injection of autologous platelet-rich plasma with the aim to rejuvenate the ovarian tissue and enable the employment of her own gametes through in-vitro fertilization. Six weeks following the autologous platelet-rich plasma treatment, a significant reduction in the patient's follicle-stimulating hormone (FSH) levels were noted. A natural in-vitro fertilization cycle led to a biochemical pregnancy, resulting in a spontaneous abortion at the 5th week of pregnancy. This is the first report of a successful autologous platelet-rich plasma application leading to pregnancy in menopause. This report uniquely contributes to the medical knowledge and challenges current practice in the context of infertility. The efficiency and safety of this treatment with regard to the reproductive system merits further investigation.
本报告介绍了一位40岁女性的病例，她从35岁起就经历了过早绝经。在拒绝卵母细胞捐赠后，她选择了卵巢内注射自体富血小板血浆，目的是使卵巢组织恢复活力，并通过体外受精使用自己的配子。自体富血小板血浆治疗六周后，患者的促卵泡激素（FSH）水平显著降低。一次自然体外受精周期导致生化妊娠，在妊娠第5周自然流产。这是第一例自体富血小板血浆成功应用导致绝经后妊娠的报告。本报告为医学知识做出了独特贡献，并对当前不孕不育领域的实践提出了挑战。这种治疗在生殖系统方面的有效性和安全性值得进一步研究。
