McAllister Matthew J, Basham Steven A, Waldman Hunter S, Smith JohnEric W, Butawan Matthew B, Bloomer Richard J
Department of Health and Human Performance, Texas State University, San Marcos, TX, USA.
Applied Physiology Lab, Department of Kinesiology, Mississippi State University, Mississippi, MS, USA.
J Diet Suppl. 2020;17(3):261-272. doi: 10.1080/19390211.2018.1515142. Epub 2018 Dec 22.
Firefighters and military personnel are exposed to a variety of stressors. The combination of mental and physical stress (i.e., dual stress challenges [DSCs]) results in significant oxidative stress (OS), which may contribute to cardiometabolic dysfunction. Curcumin (CUR) is an exogenous antioxidant that may attenuate such OS. Fourteen trained men participated in a randomized, cross-over design to investigate the impact of CUR on markers of OS resulting from DSC. CUR or placebo was ingested three days prior to, and the morning of, testing. The DSC involved 20 min of mental stress challenges during 35 min of cycling at 60% V̇O. Blood was sampled before, as well as immediately, 30 min, and 60 min after, exercise and analyzed for glutathione (GSH), superoxide dismutase (SOD), hydrogen peroxide (HO), and advanced oxidation protein products (AOPP). There was no treatment effect for any variable. However, the DSC resulted in significant reductions in SOD, HO, and AOPP at 30 and 60 min after exercise. Previous studies have shown that DSC results in significant OS compared to exercise alone. However, these data suggest the DSC was associated with reductions in postexercise markers of OS. Antioxidant therapy is likely not needed in trained men exposed to DSC.
消防员和军事人员会面临各种压力源。心理压力和身体压力的结合（即双重压力挑战[DSC]）会导致显著的氧化应激（OS），这可能会导致心脏代谢功能障碍。姜黄素（CUR）是一种外源性抗氧化剂，可能会减轻这种氧化应激。14名经过训练的男性参与了一项随机交叉设计，以研究姜黄素对双重压力挑战导致的氧化应激标志物的影响。在测试前三天以及测试当天早晨摄入姜黄素或安慰剂。双重压力挑战包括在以60%最大摄氧量进行35分钟骑行的过程中进行20分钟的心理压力挑战。在运动前、运动后即刻、30分钟和60分钟采集血液样本，分析谷胱甘肽（GSH）、超氧化物歧化酶（SOD）、过氧化氢（HO）和晚期氧化蛋白产物（AOPP）。任何变量均未出现治疗效果。然而，双重压力挑战导致运动后30分钟和60分钟时超氧化物歧化酶、过氧化氢和晚期氧化蛋白产物显著降低。先前的研究表明，与单独运动相比，双重压力挑战会导致显著的氧化应激。然而，这些数据表明，双重压力挑战与运动后氧化应激标志物的降低有关。对于面临双重压力挑战的训练有素的男性，可能不需要抗氧化治疗。
