School of Pharmacy, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.
School of Postgraduate Studies, International Medical University, No 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.
Biomed Pharmacother. 2019 Mar;111:198-208. doi: 10.1016/j.biopha.2018.12.052. Epub 2018 Dec 22.
For many years, circular ribonucleic acids (circRNAs) have been counted as aberrant splicing by-products. Advanced bioinformatics analysis and deep sequencing techniques have allowed researchers to discover more interesting facts about circRNAs. Intriguing evidence has shed light on the functions of circRNAs in many tissues. Furthermore, emerging reports showed that circRNAs are found abundantly in saliva and blood samples, suggesting that circRNAs are potential clinical biomarkers for human embryonic development, diseases progression and prognosis, in addition to its role in organogenesis and pathogenesis. The implementation of circRNAs in human developmental stages and diseases would be a tremendous discovery in the science and medical field. Therefore, circRNAs have been studied for its biological function as well as its implication in various human diseases. The aim of this review is to highlight the importance of circRNAs in cardiac, respiratory, nervous, endocrine and digestive systems. In addition, the role and impact of circRNAs in, cardiogenesis, neurogenesis and cancer have been discussed.
多年来，环状核糖核酸（circRNAs）一直被认为是异常剪接的副产物。先进的生物信息学分析和深度测序技术使研究人员能够发现更多关于 circRNAs 的有趣事实。有趣的证据表明 circRNAs 在许多组织中的功能。此外，新兴的报告表明，circRNAs 在唾液和血液样本中大量存在，这表明 circRNAs 是人类胚胎发育、疾病进展和预后的潜在临床生物标志物，除了其在器官发生和发病机制中的作用。circRNAs 在人类发育阶段和疾病中的应用将是科学和医学领域的一项重大发现。因此，人们一直在研究 circRNAs 的生物学功能及其在各种人类疾病中的作用。本文综述的目的是强调 circRNAs 在心脏、呼吸、神经、内分泌和消化系统中的重要性。此外，还讨论了 circRNAs 在心脏发生、神经发生和癌症中的作用和影响。
