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微生物代谢产物。247. 来自抗生链霉菌Tü 2706菌株的吩嗪类化合物。

Metabolites of microorganisms. 247. Phenazines from Streptomyces antibioticus, strain Tü 2706.

作者信息

Geiger A, Keller-Schierlein W, Brandl M, Zähner H

机构信息

Organisch-chemisches Laboratorium, Eidgenössische Technische Hochschule, Zürich, Switzerland.

出版信息

J Antibiot (Tokyo). 1988 Nov;41(11):1542-51. doi: 10.7164/antibiotics.41.1542.

DOI:10.7164/antibiotics.41.1542
PMID:3058669
Abstract

From a strain of Streptomyces antibioticus seven yellow phenazines were isolated. The antibacterially most active antibiotic was identified as (-)-saphenamycin, a second one with compound DC-86-Y (saphenic acid). Three compounds were new: Saphenic acid methyl ether, 6-acetylphenazine-1-carboxylic acid and an inseparable mixture of fatty acid esters of saphenic acid. Two simple phenazines were phenazine-1-carboxylic acid (tubermycin B) and unsubstituted phenazine, which was isolated for the first time from a microorganism.

摘要

从一株抗生链霉菌中分离出了七种黄色吩嗪。抗菌活性最强的抗生素被鉴定为(-)-萨芬霉素,另一种是化合物DC-86-Y(萨芬酸)。有三种化合物是新的:萨芬酸甲酯、6-乙酰吩嗪-1-羧酸以及萨芬酸脂肪酸酯的不可分离混合物。两种简单的吩嗪是吩嗪-1-羧酸(结核霉素B)和未取代的吩嗪,后者是首次从微生物中分离得到。

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