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内吩嗪A-D，来自与节肢动物相关的内共生菌环形链霉菌的新型吩嗪类抗生素。I. 分类学、发酵、分离及生物活性。

Endophenazines A-D, new phenazine antibiotics from the arthropod associated endosymbiont Streptomyces anulatus. I. Taxonomy, fermentation, isolation and biological activities.

作者信息

Gebhardt Klaus, Schimana Judith, Krastel Philipp, Dettner Konrad, Rheinheimer Joachim, Zeeck Axel, Fiedler Hans-Peter

出版信息

J Antibiot (Tokyo). 2002 Sep;55(9):794-800. doi: 10.7164/antibiotics.55.794.

DOI:10.7164/antibiotics.55.794
PMID:12458768
Abstract

Four new members of the phenazine family, endophenazines A-D, and the already known phenazine-1-carboxylic acid (tubermycin B) were detected in the culture broth of various endosymbiotic Streptomyces anulatus strains by chemical screening in a combination of TLC-staining reagents and HPLC-diode array analysis. The endosymbiotic strains were isolated from four different arthropod hosts at various sites. The new phenazine compounds showed antimicrobial activities against Gram-positive bacteria and some filamentous fungi, and herbicidal activity against Lemna minor (duckweed).

摘要

通过薄层色谱染色试剂与高效液相色谱-二极管阵列分析相结合的化学筛选方法，在多种共生内生链霉菌菌株的培养液中检测到了吩嗪家族的四个新成员，即内吩嗪A-D，以及已知的吩嗪-1-羧酸（结核霉素B）。这些共生内生菌株是从不同地点的四种不同节肢动物宿主中分离得到的。新的吩嗪化合物对革兰氏阳性菌和一些丝状真菌具有抗菌活性，对浮萍具有除草活性。

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