Instituto de Química, Universidade Federal do Rio de Janeiro, Avenida Athos da Silveira Ramos 149, 21941-909 Rio de Janeiro, Brazil.
Instituto de Biologia, Universidade Federal Fluminense, Niterói, 4020-141 Rio de Janeiro, Brazil.
Molecules. 2018 Dec 26;24(1):74. doi: 10.3390/molecules24010074.
Soybeans display strategic potential in food security as a source of protein and functional bioactives for human consumption. Polyphenols and other bioactive compounds can be recovered after an aqueous extraction from soybean meal, a byproduct of soy oil refining. The objective of the present study was to compile and quantify compounds from soybean oil refinery by-products, providing information about valuable bioactive phytochemicals, their bioaccessibility and potential bioactivities. Genistin, daidzin, glycitin and malonylgenistin were the predominant isoflavones, and the overall bioaccessibility of their glycosidic forms was of nearly 75%. Sixteen phenolics were identified and caffeic acid, 5-caffeoylquinic chlorogenic acid and hesperidin were the most predominant. Approximately 30% of gallic acid, syringic acid, vanillic acid and myricetin were released and the antioxidant capacity of aqueous extract was enhanced after simulated in vitro gastro intestinal digestion. The ability of aqueous soybean meal extract to inhibit lipid peroxidation was higher than natural and synthetic food antioxidants. Antimicrobial activity against several foodborne pathogens and antitumoral activity towards human glioblastoma cell line were also observed, but the aqueous extract showed no cytotoxicity to healthy murine cells. Compounds derived from the aqueous soybean meal extract have the potential to be used as health promoting agents.
大豆作为人类食用的蛋白质和功能性生物活性物质的来源，在食品安全方面具有战略潜力。多酚和其他生物活性化合物可以从大豆蛋白粉（大豆油精炼的副产品）的水提取中回收。本研究的目的是从大豆油精炼的副产物中综合和定量化合物，提供有关有价值的生物活性植物化学物质、它们的生物利用度和潜在生物活性的信息。染料木苷、大豆苷、大豆苷元和丙二酰基染料木苷是主要的异黄酮，其糖苷形式的总体生物利用度接近 75%。鉴定出 16 种酚类化合物，其中咖啡酸、5-咖啡酰奎尼酸和橙皮苷含量最高。约 30%的没食子酸、丁香酸、香草酸和杨梅素被释放出来，并且在模拟的体外胃肠道消化后，水提物的抗氧化能力增强。水提大豆蛋白粉抑制脂质过氧化的能力高于天然和合成食品抗氧化剂。还观察到对几种食源性致病菌的抗菌活性和对人神经胶质瘤细胞系的抗肿瘤活性，但水提物对健康的鼠细胞没有细胞毒性。源自水提大豆蛋白粉的化合物具有作为促进健康的物质的潜力。
