Kuswardhani Ra Tuty, Wiradharma Ketut Gede, Kandarini Yenny, Widiana Gde Raka, Martadiani Elysanti Dwi
Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah Hospital, Denpasar, Indonesia,
Department of Internal Medicine, Sumbawa District Hospital, Sumbawa Besar, Indonesia.
Int J Gen Med. 2018 Dec 18;12:1-6. doi: 10.2147/IJGM.S178276. eCollection 2019.
The aim of this study was to analyze the association of the carotid intima-media thickness (CIMT) with various parameters in patients on maintenance hemodialysis (mHD).
A cross-sectional study was conducted, enrolling 68 subjects (41 men, 27 women) on mHD in the Hemodialysis Unit, Sanglah Hospital, Denpasar, Indonesia. CIMT was measured with B-mode ultrasonography using a USG Sonoace 8000 and a 7.5 MHz linear transducer.
CIMT was higher in subjects with cardiovascular disease (CVD) compared with those without CVD (0.6494 vs 0.7288 mm; =0.026), and in men compared with women (0.7056 vs 0.6141 mm; =0.003). CIMT was correlated with age (=0.607; <0.001), plasma albumin (=-0.291, =0.016), serum phosphate (=-0.294, =0.015), calcium-phosphate product (=-0.284, =0.011), and plasma high-sensitivity C-reactive protein (=0.279, =0.030). However, after multiple linear regression testing, only age consistently had a role in determining the CIMT value (β=0.452, <0.001).
Subjects with CVD have higher CIMT than those without CVD and men had higher CIMT than women. In addition, older age, higher high-sensitivity C-reactive protein, and lower albumin, phosphate, and calcium-phosphate product levels were correlated with higher CIMT. Age was the most important marker for CIMT in subjects on mHD.
本研究旨在分析维持性血液透析（mHD）患者的颈动脉内膜中层厚度（CIMT）与各种参数之间的关联。
进行了一项横断面研究，纳入了印度尼西亚登巴萨桑格拉医院血液透析科的68名接受mHD治疗的受试者（41名男性，27名女性）。使用USG Sonoace 8000和7.5 MHz线性换能器通过B型超声测量CIMT。
患有心血管疾病（CVD）的受试者的CIMT高于未患CVD的受试者（0.6494对0.7288 mm；P = 0.026），男性的CIMT高于女性（0.7056对0.6141 mm；P = 0.003）。CIMT与年龄（r = 0.607；P < 0.001）、血浆白蛋白（r = -0.291，P = 0.016）、血清磷酸盐（r = -0.294，P = 0.015）、钙磷乘积（r = -0.284，P = 0.011）以及血浆高敏C反应蛋白（r = 0.279，P = 0.030）相关。然而，经过多元线性回归测试后，只有年龄始终对CIMT值起决定作用（β = 0.452，P < 0.001）。
患有CVD的受试者的CIMT高于未患CVD的受试者，男性的CIMT高于女性。此外，年龄较大、高敏C反应蛋白水平较高以及白蛋白、磷酸盐和钙磷乘积水平较低与较高的CIMT相关。年龄是mHD受试者CIMT的最重要标志物。
