[紫檀芪在癌症研究中的新作用]
[Emerging Actions of Pterostilebene on Cancer Research].
作者信息
Zhang Xiaoyan, Zhang Jiao, Xu Liqun, Ma Zhiqiang, Di Shouyin, Gao Yuan, Li Xiaofei, Yan Xiaolong, Zhang Hongmei
机构信息
Department of Clinical Oncology, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China.
Department of Thoracic Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2018 Dec 20;21(12):931-936. doi: 10.3779/j.issn.1009-3419.2018.12.01.
Abstract
Pterostilbene (3,5-dimethoxy-4'-hydroxystilbene) is a polyphenolic compound primarily found in blueberries, grapes, and a tree wood, pterocarpus marsupium. Studies demonstrate that pterostilbene inhibits a variety of cancers, such as lung, breast, stomach, colon, etc. The anti-cancer activities are related to the regulation of several hallmarks of cancer. Moreover, pterostilbene exhibits much greater bioavailability and bioactivity than resveratrol which warrants further investigation in the anti-cancer functions and mechanisms. .
摘要
紫檀芪（3,5 - 二甲氧基 - 4'- 羟基芪）是一种主要存在于蓝莓、葡萄以及一种树木——印度紫檀中的多酚类化合物。研究表明，紫檀芪能抑制多种癌症，如肺癌、乳腺癌、胃癌、结肠癌等。其抗癌活性与癌症的几个特征的调节有关。此外，紫檀芪比白藜芦醇具有更高的生物利用度和生物活性，这值得在抗癌功能和机制方面进行进一步研究。
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J Food Drug Anal. 2017 Jan;25(1):134-147. doi: 10.1016/j.jfda.2016.07.004. Epub 2016 Sep 22.
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Autophagy-inducing effect of pterostilbene: A prospective therapeutic/preventive option for skin diseases.白藜芦醇诱导自噬的作用：皮肤病有前景的治疗/预防选择。
J Food Drug Anal. 2017 Jan;25(1):125-133. doi: 10.1016/j.jfda.2016.10.022. Epub 2016 Dec 11.
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Regulation of microRNA using promising dietary phytochemicals: Possible preventive and treatment option of malignant mesothelioma.利用有前景的膳食植物化学物调控 microRNA：恶性间皮瘤的潜在预防和治疗选择。
Biomed Pharmacother. 2017 Oct;94:1197-1224. doi: 10.1016/j.biopha.2017.07.075. Epub 2017 Aug 23.
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Pterostilbene exerts anticancer activity on non-small-cell lung cancer via activating endoplasmic reticulum stress.紫檀芪通过激活内质网应激发挥对非小细胞肺癌的抗癌活性。
Sci Rep. 2017 Aug 14;7(1):8091. doi: 10.1038/s41598-017-08547-0.
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Anti-inflammatory activity of natural stilbenoids: A review.天然芪类化合物的抗炎活性：综述。
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