a Faculty of Pharmacy, Department of Analytical Chemistry , Ankara University , Ankara , Turkey.
b Faculty of Science and Art, Department of Chemistry , Hitit University , Çorum , Turkey.
Crit Rev Anal Chem. 2019;49(4):306-323. doi: 10.1080/10408347.2018.1527206. Epub 2018 Dec 29.
In the past decades, patients who have chemotherapy treatment have considerably increased number. At this point, the development of rapid precise, and reliable methods are very important to analyze cancer drugs from their dosage forms, animals or human biological samples. Among all the analytical methods, electrochemical methods hold an important position with their unique properties such as specificity in the biological recognition process, fast response, and their reliability and do not need a pretreatment process. Chromatographic methods are also used in a wide range of analytical applications for the analyses of anticancer drugs. The power of chromatography comes from its ability to separate a mixture of analytes and determination of their concentrations. Chromatographic techniques can mainly be divided into gas, liquid, and supercritical fluid chromatography. In the frame of this information, this review is aimed to provide basic principles of electroanalytical and high-performance liquid chromatography methods for the analysis of cancer drugs. In addition, some selected applications for electrochemistry-related techniques and high-performance liquid chromatography, for the determination of anti-cancer pharmaceuticals published in the last five years are also discussed.
在过去的几十年中，接受化疗治疗的患者数量大幅增加。在这一点上，开发快速、准确和可靠的方法对于分析癌症药物的剂型、动物或人体生物样本非常重要。在所有分析方法中，电化学方法因其在生物识别过程中的特异性、快速响应以及可靠性而具有独特的性质，并且不需要预处理过程，因此占有重要地位。色谱方法也广泛应用于分析抗癌药物。色谱法的强大之处在于它能够分离混合物中的分析物并确定它们的浓度。色谱技术主要可分为气相色谱、液相色谱和超临界流体色谱。在这一信息的框架下，本文旨在提供用于分析癌症药物的电化学和高效液相色谱方法的基本原理。此外，还讨论了过去五年中发表的与电化学相关技术和高效液相色谱法相关的一些用于测定抗癌药物的应用。
