一种来自内生真菌喙突埃里格孢LPC - 001的新型细胞毒性12元大环内酯。
A new cytotoxic 12-membered macrolactone from the endophytic fungus Exserohilum rostratum LPC-001.
作者信息
Lin Peng-Cheng, Wu Yu-Zhuo, Bao Ting-Wen, Wang Ya-Nan, Shang Xiao-Ya, Lin Sheng
机构信息
a College of Pharmaceutical Sciences , Qinghai university for nationalities , Xining , 810000 , China.
b State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , 100050 , China.
出版信息
J Asian Nat Prod Res. 2018 Nov;20(11):1093-1100. doi: 10.1080/10286020.2018.1518322. Epub 2018 Dec 30.
A new oxacyclododecindione-type macrolactone, (13R,14S,15R)-13-hydroxy-14-deoxyoxacyclododecindione (1), has been obtained from the solid cultures of the fungus Exserohilum rostratum, a fungal strain endophytic in Gymnadenia conopsea. Its structure, including the absolute configuration, was extensively established by 1D and 2D NMR data, the modified Mosher method, and a combination of experimental and theoretically calculated electronic circular dichroism (ECD) spectra. Compound 1 showed weak selective cytotoxicity against the A549 lung cell line with an IC value of 9.2 µM.
一种新的氧杂环十二碳二酮型大环内酯，（13R，14S，15R）-13-羟基-14-脱氧氧杂环十二碳二酮（1），是从真菌长喙突脐孢（Exserohilum rostratum）的固体培养物中获得的，该真菌是手参（Gymnadenia conopsea）中的一种内生真菌菌株。其结构，包括绝对构型，通过一维和二维核磁共振数据、改良的莫舍尔方法以及实验和理论计算的电子圆二色光谱（ECD）的组合得到了广泛的确立。化合物1对A549肺癌细胞系表现出较弱的选择性细胞毒性，IC值为9.2 μM。
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