Sappapan Ruengrit, Sommit Damrong, Ngamrojanavanich Nattaya, Pengpreecha Somchai, Wiyakrutta Suthep, Sriubolmas Nongluksna, Pudhom Khanitha
Program in Biotechnology, Chulalongkorn University, Bangkok 10330 Thailand.
J Nat Prod. 2008 Sep;71(9):1657-9. doi: 10.1021/np8004024. Epub 2008 Sep 6.
A new analogue of monocerin, 11-hydroxymonocerin (2), along with monocerin (1) and 12-hydroxymonocerin (3) were isolated from cultures of Exserohilum rostratum, a fungal strain endophytic in Stemona sp. The structure of 2 was determined by analysis of NMR and MS data and by comparison of spectroscopic data to those of 1. Monocerin (1) and 11-hydroxymonocerin (2) displayed activity against Plasmodium falciparum (K1, multidrug-resistant strain) with IC50 values of 0.68 and 7.70 microM, respectively. None of the compounds were cytotoxic against any of the tumor cell lines tested.
从百部内生真菌喙突埃里希菌（Exserohilum rostratum）的培养物中分离出了一种新的单孢菌素类似物11-羟基单孢菌素（2），以及单孢菌素（1）和12-羟基单孢菌素（3）。通过对核磁共振（NMR）和质谱（MS）数据的分析，并将光谱数据与1的光谱数据进行比较，确定了2的结构。单孢菌素（1）和11-羟基单孢菌素（2）对恶性疟原虫（K1，多药耐药菌株）具有活性，IC50值分别为0.68和7.70微摩尔。这些化合物对所测试的任何肿瘤细胞系均无细胞毒性。
