地依瑞醇类：来源于澳大利亚白蚁巢内生真菌绿色木霉 CMB-TN16 的倍半萜二聚体。
Divirensols: Sesquiterpene Dimers from the Australian Termite Nest-Derived Fungus Trichoderma virens CMB-TN16.
机构信息
Division of Chemistry and Structural Biology, Institute for Molecular Bioscience , The University of Queensland , St Lucia , QLD 4072 , Australia.
Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine , Shanghai Jiao Tong University , Shanghai , 200127 , People's Republic of China.
出版信息
J Nat Prod. 2019 Jan 25;82(1):87-95. doi: 10.1021/acs.jnatprod.8b00746. Epub 2018 Dec 31.
A chemical investigation of the Australian termite nest-derived fungus Trichoderma virens CMB-TN16 yielded the known sesquiterpene gliocladic acid (1), together with two new acetylated analogues, 3-acetylgliocladic acid (2) and 14-acetylgliocladic acid (3), and seven new dimeric congeners, divirensols A-G (4-10). All metabolites were identified by detailed spectroscopic analysis, supported by biosynthetic considerations, and were assessed for antibacterial and cytotoxic properties. The divirensols are examples of an exceptionally rare class of dimeric sesquiterpene, likely linked via a highly convergent biosynthetic pathway. HPLC-DAD-MS analysis of the crude fungal extract detected ions attributed to putative monomeric biosynthetic precursors.
对澳大利亚白蚁巢真菌绿色木霉 CMB-TN16 的化学成分研究得到了已知的倍半萜类化合物gliocladic 酸（1），以及两个新的乙酰化类似物 3-乙酰基gliocladic 酸（2）和 14-乙酰基gliocladic 酸（3），以及七个新的二聚体同系物，divirensols A-G（4-10）。所有代谢物均通过详细的光谱分析确定，得到生物合成的支持，并评估了其抗菌和细胞毒性特性。Divirensols 是一类非常罕见的倍半萜二聚体的例子，可能通过高度趋同的生物合成途径连接。粗真菌提取物的 HPLC-DAD-MS 分析检测到了归因于假定单体生物合成前体的离子。
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