School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China; Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology (Sun Yat-Sen University), Guangzhou 510275, China.
MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China.
Ecotoxicol Environ Saf. 2019 Mar;169:822-828. doi: 10.1016/j.ecoenv.2018.11.101. Epub 2018 Nov 29.
In the present study, concentrations of bisphenol A (BPA) and its six alternatives were quantified in serum samples collected from elder population living around an e-waste recycling facilities as well as an reference area in China. BPA, bisphenol AF (BPAF), and bisphenol F (BPF) were frequently detected (detection rates: > 65%) in serum samples collected from residents living near e-waste dismantling facilities, with geometric mean (GM) concentrations of 3.2, 0.0074, and 0.062 ng/mL, respectively. The detection frequencies of other four bisphenols (BPs) in serum samples were lower than 25%, regardless of the sampling areas. Significant difference (Mann-Whitney U-test, p < 0.05) was observed in the serum concentration of BPA, but not BPAF and BPF, between the e-waste recycling and reference areas. This finding indicated e-waste dismantling activities are correlated with human BPA exposure. Significant higher (p < 0.05) detection rates of donors who had abnormal fasting blood glucose (FBG) levels were found in e-waste recycling areas (45%) than those found in reference area. Our results suggested BPA and BPAF exposure might associated with abnormal FBG in participants living in e-waste sites. To our knowledge, this study is first determination of BPs in serum samples and assessment of health risk of elderly people from BPs exposure in e-waste dismantling area.
在本研究中，定量测定了生活在中国电子废物拆解设施周围及参照区老年人群血清中双酚 A（BPA）及其 6 种替代品的浓度。在来自电子废物拆解设施附近居民的血清样本中，经常检测到双酚 AF（BPAF）和双酚 F（BPF）（检出率：>65%），几何平均浓度（GM）分别为 3.2、0.0074 和 0.062ng/mL。无论采样区域如何，其他四种双酚（BPs）在血清样本中的检出频率均低于 25%。电子废物回收区和参照区之间 BPA 的血清浓度存在显著差异（Mann-Whitney U 检验，p<0.05），但 BPAF 和 BPF 的血清浓度无显著差异。这一发现表明，电子废物拆解活动与人类 BPA 暴露有关。在电子废物回收区，空腹血糖（FBG）水平异常的供体的检出率显著更高（p<0.05，45%）。我们的研究结果表明，BPA 和 BPAF 的暴露可能与生活在电子废物场的参与者的异常 FBG 有关。据我们所知，这是首次在血清样本中测定 BPs，并评估电子废物拆解区老年人接触 BPs 的健康风险。
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