Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Ultrasound Med Biol. 2019 Mar;45(3):741-748. doi: 10.1016/j.ultrasmedbio.2018.11.003. Epub 2018 Dec 29.
Lung ultrasound surface wave elastography (LUSWE) is a novel non-invasive technique for measuring superficial lung tissue stiffness. The purpose of the study described here was to develop LUSWE for assessment of progression in patients with interstitial lung disease (ILD). In this study, LUSWE was used to measure changes in lung surface wave speeds at 100, 150 and 200 Hz through six intercostal lung spaces for 52 patients with ILD. The mean age was 63.1 ± 12.0 y (range: 20-85, 23 male and 29 female). The follow-up interval was 9.2 ± 3.5 mo depending on each patient's return appointment and availability. For each patient, disease progression between the baseline and follow-up tests was evaluated clinically using a 7-point Likert scale comprising three grades of improvement (mild, moderate, marked), unchanged status and three grades of worsening (mild, moderate, marked). Clinical assessments were based on changes in pulmonary function tests together with high-resolution computed tomography, echocardiography and clinical evaluations. This study illustrates the correlations between changes in lung surface wave speed and clinical assessments. Correlations of changes in lung surface wave speed at lower lateral and posterior portions of the lung portions with clinical assessments were good. LUSWE provides quantitative global and regional changes in lung surface wave speed that may be useful for quantitative assessment of progression of ILD.
肺部超声表面波弹性成像（LUSWE）是一种用于测量浅层肺组织硬度的新型无创技术。本研究旨在开发 LUSWE 以评估间质性肺疾病（ILD）患者的疾病进展。在这项研究中，通过六个肋间肺间隙，使用 LUSWE 测量了 52 名 ILD 患者在 100、150 和 200Hz 时的肺表面波速度的变化。患者的平均年龄为 63.1±12.0 岁（范围：20-85 岁，23 名男性和 29 名女性）。随访间隔为 9.2±3.5 个月，具体取决于每位患者的复诊时间和可就诊情况。对于每位患者，通过 7 点 Likert 量表对基线和随访测试之间的疾病进展进行临床评估，该量表包含三个改善等级（轻度、中度、显著）、不变状态和三个恶化等级（轻度、中度、显著）。临床评估基于肺功能测试的变化以及高分辨率计算机断层扫描、超声心动图和临床评估。本研究说明了肺表面波速度变化与临床评估之间的相关性。肺下部和后部的肺表面波速度变化与临床评估的相关性良好。LUSWE 提供了肺表面波速度的定量整体和区域变化，可能有助于定量评估 ILD 的进展。
