Thompson James D, Harari Paul M, Hartig Gregory K
Department of Surgery and the Department of Human Oncology University of Wisconsin School of Medicine and Public Health Madison Wisconsin.
Laryngoscope Investig Otolaryngol. 2018 Oct 15;3(6):446-449. doi: 10.1002/lio2.181. eCollection 2018 Dec.
To evaluate changing age demographics over a 15-year period for patients with HPV-associated oropharyngeal squamous cell carcinoma (OPSCC).
Retrospective review of patients identified with p16-positive OPSCC at our institution over a 15-year timeframe. : p16-positive immunohistochemistry was used as a surrogate for HPV-associated OPSCC. Patients were categorized according to year of diagnosis (2002-2010 versus 2011-2016). Mean age and proportion of patients over age 65 were statistically evaluated and compared.
From 2002 to 2010, 100 patients were identified with p16-positive OPSCC, mean age at diagnosis was 55.2, and the proportion of patients over 65 was 10.0%. From 2011 to 2016, 188 patients were identified with p16-positive OPSCC, mean age was 58.5, and the proportion of patients over 65 was 19.6%. Both the mean age difference and the difference in proportion of patients over 65 were statistically significant ( = .001 and = .034, respectively).
The mean age at diagnosis and proportion of patients over 65 has increased over the past 15 years at our institution. This data suggests that HPV-associated OPSCC is being diagnosed more frequently in older persons and that the age demographic may be shifting. Confirmation of this trend with larger patient numbers on a national level will be valuable. This study highlights the importance of maintaining a high clinical suspicion for HPV-associated OPSCC regardless of patient age.
评估人乳头瘤病毒（HPV）相关的口咽鳞状细胞癌（OPSCC）患者在15年期间年龄分布的变化情况。
对我院在15年时间内确诊为p16阳性OPSCC的患者进行回顾性研究。采用p16阳性免疫组化作为HPV相关OPSCC的替代指标。根据诊断年份（2002 - 2010年与2011 - 2016年）对患者进行分类。对平均年龄和65岁以上患者的比例进行统计学评估和比较。
2002年至2010年，确诊为p16阳性OPSCC的患者有100例，诊断时的平均年龄为55.2岁，65岁以上患者的比例为10.0%。2011年至2016年，确诊为p16阳性OPSCC的患者有188例，平均年龄为58.5岁，65岁以上患者的比例为19.6%。平均年龄差异和65岁以上患者比例的差异均具有统计学意义（分别为P = 0.001和P = 0.034）。
在过去15年里，我院诊断时的平均年龄和65岁以上患者的比例有所增加。该数据表明，HPV相关的OPSCC在老年人中诊断更为频繁，年龄分布可能正在发生变化。在全国范围内用更多患者数量证实这一趋势将很有价值。本研究强调了无论患者年龄如何，对HPV相关OPSCC保持高度临床怀疑的重要性。
4级。
