Department of Neurology, Mayo Clinic, Rochester, Minnesota 55902, USA.
Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota 55902, USA.
J Acoust Soc Am. 2018 Dec;144(6):3364. doi: 10.1121/1.5082210.
This study examined the rate of producing alternating motion rates, sequential motion rates (SMRs), and repeated words in 27 individuals with the semantic variant of Primary Progressive Aphasia (svPPA). Only the rate of producing SMRs was significantly elevated in svPPA compared to controls. This may be associated with concomitant neuropsychiatric symptoms in svPPA, as correlation analysis showed a relationship between increased SMR rate and the Neuropsychiatric Inventory Questionnaire, which documented anxiety and disinhibition. Future studies will assess these findings in a larger cohort and work to better understand if this phenomenon is a manifestation of behavioral and/or motor changes.
本研究检测了 27 名语义变异型原发性进行性失语症（svPPA）患者产生交替运动率、序列运动率（SMR）和重复词的比率。与对照组相比，只有产生 SMR 的速率在 svPPA 中显著升高。这可能与 svPPA 同时存在的神经精神症状有关，因为相关分析显示 SMR 率的增加与神经精神疾病问卷之间存在关系，该问卷记录了焦虑和抑制障碍。未来的研究将在更大的队列中评估这些发现，并努力更好地理解这种现象是否是行为和/或运动变化的表现。
