Majer M, Hilfenhaus J, Mauler R, Hennessen W
MMW Munch Med Wochenschr. 1978 Mar 3;120(9):287-8.
In order to improve the tolerance of rabies vaccine from human diploid cell cultures, the rabies virus antigen is purified in the sucrose density gradient by means of a flow ultracentrifuge. The purified virus has a specific infectiosity of 10(9) LD50 and a speicific activity of 250 units "relative activity" per 1 mg protein. The purified vaccine has been shown to be well tolerated, effective and stable.