急性肾损伤与神经免疫轴
AKI and the Neuroimmune Axis.
机构信息
Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA.
Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA.
出版信息
Semin Nephrol. 2019 Jan;39(1):85-95. doi: 10.1016/j.semnephrol.2018.10.008.
Neuroimmune interaction is an emerging concept, wherein the nervous system modulates the immune system and vice versa. This concept is gaining attention as a novel therapeutic target in various inflammatory diseases including acute kidney injury (AKI). Vagus nerve stimulation or treatment with pulsed ultrasound activates the cholinergic anti-inflammatory pathway to prevent AKI in mice. The kidneys are innervated by sympathetic efferent and sensory afferent neurons, and these neurons also may play a role in the modulation of inflammation in AKI. In this review, we discuss several neural circuits with respect to the control of renal inflammation and AKI as well as optogenetics as a novel tool for understanding these complex neural circuits.
神经免疫相互作用是一个新兴概念，其中神经系统调节免疫系统，反之亦然。这个概念作为一种新的治疗靶点，在包括急性肾损伤 (AKI) 在内的各种炎症性疾病中受到关注。迷走神经刺激或脉冲超声治疗激活胆碱能抗炎途径，可预防小鼠的 AKI。肾脏受交感传出和感觉传入神经元支配，这些神经元也可能在调节 AKI 中的炎症中发挥作用。在这篇综述中，我们讨论了几个与肾脏炎症和 AKI 控制有关的神经回路，以及光遗传学作为一种理解这些复杂神经回路的新工具。
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