Complement-dependent serum: neuroelectric blocking activity in multiple sclerosis.
作者信息
Schauf C L, Schauf V, Davis F A, Mizen M R
出版信息
Neurology. 1978 May;28(5):426-30. doi: 10.1212/wnl.28.5.426.
PMID:306076
Abstract
In attempting to discover a relationship between the neurologic and immunologic abnormalities in multiple sclerosis, we found a serum factor that inhibits the ventral root response in isolated, perfused frog spinal cords. This effect is correlated with disease activity. Blocking activity of the serum was lost by heating to 56 degrees C, restored by adding complement, and was found in the serum IgG fraction. There was no correlation of neuroelectric blocking activity with measles complement-fixing antibody. An antibody other than that to measles virus may thus have a role in the pathogenesis of multiple sclerosis.
摘要
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