Valon Léo, Levayer Romain
Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris, 75015, France.
Biol Cell. 2019 Mar;111(3):51-66. doi: 10.1111/boc.201800075. Epub 2019 Jan 17.
Cells and tissues are exposed to multiple mechanical stresses during development, tissue homoeostasis and diseases. While we start to have an extensive understanding of the influence of mechanics on cell differentiation and proliferation, how excessive mechanical stresses can also lead to cell death and may be associated with pathologies has been much less explored so far. Recently, the development of new perturbative approaches allowing modulation of pressure and deformation of tissues has demonstrated that compaction (the reduction of tissue size or volume) can lead to cell elimination. Here, we discuss the relevant type of stress and the parameters that could be causal to cell death from single cell to multicellular systems. We then compare the pathways and mechanisms that have been proposed to influence cell survival upon compaction. We eventually describe the relevance of compaction-induced death in vivo, and its functions in morphogenesis, tissue size regulation, tissue homoeostasis and cancer progression.
在发育、组织稳态和疾病过程中，细胞和组织会受到多种机械应力的作用。虽然我们开始广泛了解力学对细胞分化和增殖的影响，但到目前为止，对于过度的机械应力如何导致细胞死亡以及可能与病理学相关的研究还很少。最近，新的微扰方法的发展使得对组织压力和变形的调节成为可能，这表明压实（组织大小或体积的减小）会导致细胞清除。在这里，我们讨论了从单细胞到多细胞系统中可能导致细胞死亡的相关应力类型和参数。然后，我们比较了为影响压实后细胞存活而提出的途径和机制。我们最终描述了压实诱导的死亡在体内的相关性，及其在形态发生、组织大小调节、组织稳态和癌症进展中的作用。
