Haron E, Anaissie E, Dumphy F, McCredie K, Fainstein V
Department of Medical Specialties, University of Texas, M. D. Anderson Hospital and Tumor Institute, Houston 77030.
Rev Infect Dis. 1988 Nov-Dec;10(6):1182-6. doi: 10.1093/clinids/10.6.1182.
Fungi of the genus Hansenula have rarely been reported as pathogenic in humans. A case of catheter-related Hansenula anomala fungemia in a patient with acute leukemia in remission is presented, and the clinical features of 11 additional patients infected with Hansenula species are reviewed. The spectrum of disease with these organisms ranges from asymptomatic fungemia to life-threatening disseminated infection. Predisposing factors appear to be immunosuppression, use of intravenous devices, and previous treatment with antibacterial drugs. Clinical experience and limited in vitro susceptibility data show that amphotericin B remains the drug of choice in the treatment of hansenula infections.
汉逊酵母属真菌极少被报道可致人类致病。本文报告了1例缓解期急性白血病患者发生的与导管相关的异常汉逊酵母菌血症病例，并对另外11例感染汉逊酵母属菌种的患者的临床特征进行了回顾。这些微生物所致疾病谱范围从无症状菌血症到危及生命的播散性感染。易感因素似乎包括免疫抑制、静脉装置的使用以及既往使用抗菌药物治疗。临床经验和有限的体外药敏数据表明，两性霉素B仍然是治疗汉逊酵母感染的首选药物。
