Medical Research Council/WITS Developmental Pathways for Health Research Unit (DPHRU), Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa.
BMJ Open. 2019 Jan 3;9(1):e024446. doi: 10.1136/bmjopen-2018-024446.
To present the protocol of a systematic review and meta-analysis of the available evidence examining the association between sex hormones and type 2 diabetes risk in ageing men and women of African descent.
We shall conduct a comprehensive search of published studies that examined the association between sex hormones and type 2 diabetes risk in men and women aged ≥40 years from 01/01/1980 to 31/03/2018 with no language restriction. Databases to be searched include: PubMed, Scopus, Cochrane Library, Cumulative Index to Nursing and Allied Health, ISI Web of Science, Clinical Trial registries, Google Scholar and institutional websites such as the WHO, American Diabetes Association, International Diabetes Federation, World Diabetes Foundation, European Association for the Study of Diabetes, African Journal Online and ProQuest databases. This protocol is developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines. Independent screening for eligible studies using defined criteria and data extraction, will be completed in duplicate. Discrepancies will be resolved by consensus or consultation with a third researcher. Risk of bias of included studies will be assessed by the appropriate Cochrane risk of bias tool. The overall association estimates will be pooled using appropriate meta-analytic techniques. Heterogeneity will be assessed using Cochrane Q statistic and the inconsistency index (I). The random effects model will be used to calculate a pooled estimate.
No ethics clearance is required as no primary data will be collected. The systematic review and meta-analysis are part of a PhD project at WITS University (Johannesburg, South Africa) and results will be presented at conferences and published in a peer-review journal. The results will guide future population specific interventions.
CRD42017074581.
提出一项系统评价和荟萃分析的方案，对现有证据进行综述，以检验性激素与非裔老年男性和女性 2 型糖尿病风险之间的相关性。
我们将全面检索 1980 年 1 月 1 日至 2018 年 3 月 31 日期间发表的研究，这些研究检查了年龄≥40 岁的男性和女性中性激素与 2 型糖尿病风险之间的相关性，语言限制不限。将搜索的数据库包括：PubMed、Scopus、Cochrane 图书馆、护理与联合健康累积索引、ISI Web of Science、临床试验注册处、Google Scholar 以及机构网站，如世界卫生组织、美国糖尿病协会、国际糖尿病联合会、世界糖尿病基金会、欧洲糖尿病研究协会、非洲在线杂志和 ProQuest 数据库。本方案是根据系统评价和荟萃分析方案的首选报告项目制定的。将使用定义的标准和数据提取进行独立的合格研究筛选，将重复进行。如有分歧，将通过协商或咨询第三位研究人员解决。将使用适当的 Cochrane 偏倚风险工具评估纳入研究的偏倚风险。将使用适当的荟萃分析技术汇总总体关联估计值。使用 Cochrane Q 统计量和不一致性指数（I）评估异质性。将使用随机效应模型计算汇总估计值。
由于不会收集原始数据，因此不需要伦理批准。系统评价和荟萃分析是威特沃特斯兰德大学（南非约翰内斯堡）博士项目的一部分，结果将在会议上展示，并发表在同行评议期刊上。结果将指导未来针对特定人群的干预措施。
PROSPERO 注册号：CRD42017074581。
