From the Stroke Program (R.J.L., L.D.L., D.B.Z., K.A.K., L.E.S., J.F.B., D.A.L., D.L.B., L.B.M.), Department of Epidemiology (L.D.L., E.C.C., L.B.M.), Department of Biostatistics (B.N.S.), and Department of Internal Medicine (D.A.L.), University of Michigan, Ann Arbor.
Neurology. 2019 Feb 5;92(6):e560-e566. doi: 10.1212/WNL.0000000000006878. Epub 2019 Jan 4.
To determine using a population-based study whether midlife stroke patients having a primary care physician (PCP) at the time of first stroke have a lower risk of stroke recurrence and mortality than those who do not have a PCP.
First-ever ischemic stroke patients 45 to 64 years of age at stroke onset were ascertained through the Brain Attack Surveillance in Corpus Christi (BASIC) project from 2000 to 2013 in Texas. Cox proportional hazards models were used to examine the association between not having a PCP and stroke recurrence or all-cause mortality in separate models. Cases were followed up for up to 5 years or until December 31, 2013, whichever came first. Cases were censored for recurrence if they died before experiencing a recurrent event. We adjusted for clinical risk factors that could be associated with having a PCP and recurrence or mortality.
There were 663 first-occurrence ischemic stroke cases. Of these, 77% had a PCP, 43% were female, and average age was 55.6 years. Five-year recurrence risk was 14.6%, and mortality risk was 19.2%. Not having a PCP was associated with higher recurrence risk (adjusted hazard ratio 1.75, 95% confidence interval 1.02-3.02). Having a PCP was not associated with mortality. Sensitivity analyses showed that results were robust to different ways to adjust for chronic conditions.
This study found lower rates of stroke recurrence among those with a PCP at the time of first stroke. Future studies could determine the value of establishing a PCP before stroke hospital discharge for secondary stroke prevention.
通过一项基于人群的研究,确定中年卒中患者在首次卒中时是否有初级保健医生(PCP)比没有 PCP 的患者卒中复发和死亡风险更低。
2000 年至 2013 年,在德克萨斯州通过脑卒中超监护察项目(BASIC)确定了发病时年龄在 45 至 64 岁的首次缺血性卒中患者。使用 Cox 比例风险模型分别在单独的模型中检查无 PCP 与卒中复发或全因死亡率之间的关联。对病例进行了长达 5 年的随访,或直至 2013 年 12 月 31 日,以先到者为准。如果病例在复发前死亡,则对复发进行删失。我们调整了可能与 PCP 和复发或死亡率相关的临床危险因素。
共有 663 例首发缺血性卒中病例。其中,77%有 PCP,43%为女性,平均年龄为 55.6 岁。5 年复发风险为 14.6%,死亡率风险为 19.2%。没有 PCP 与更高的复发风险相关(调整后的风险比 1.75,95%置信区间 1.02-3.02)。有 PCP 与死亡率无关。敏感性分析表明,结果在不同的慢性疾病调整方式下都是稳健的。
本研究发现,在首次卒中时有 PCP 的患者卒中复发率较低。未来的研究可以确定在卒中出院后建立 PCP 以进行二级卒中预防的价值。