• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

前列腺癌中组蛋白赖氨酸甲基转移酶遗传异常的综合分析。

Integrated Analysis of Genetic Abnormalities of the Histone Lysine Methyltransferases in Prostate Cancer.

机构信息

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, AL, China (mainland).

Institute of Urology of Hubei Province, Wuhan, Hubei, China (mainland).

出版信息

Med Sci Monit. 2019 Jan 7;25:193-239. doi: 10.12659/MSM.912294.

DOI:10.12659/MSM.912294
PMID:30616239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6330996/
Abstract

BACKGROUND The histone methyltransferase (HMT) family includes histone lysine methyltransferases (HKMTs) and histone/protein arginine methyltransferases (PRMTs). The role of HMT gene variants in prostate cancer remains unknown. Therefore, this study aimed to evaluate HMT gene variants in the pathogenesis and prognosis of human prostate cancer, using in vitro cell studies and bioinformatics analysis. MATERIAL AND METHODS Integrative bioinformatics analysis of the expression of 51 HMT genes in human prostate cancer was based on datasets from the Cancer Genome Atlas (TCGA). Correlation and regression analysis were used to identify critical HMTs in prostate cancer. Kaplan-Meier and the area under the receiver operating characteristics curve (AUROC) were performed to evaluate the function of the HMTs on prognosis. Gene expression and function of 22Rv1 human prostate carcinoma cells were studied. RESULTS The HMT genes identified to have a role in the pathogenesis of prostate cancer included the EZH2, SETD5, PRDM12, NSD1, SETD6, SMYD1, and the WHSC1L1 gene. The EZH2, SETD5, and SMYD1 genes were selected as a prognostic panel, with the SUV420H2 HMT gene. SETD2, NSD1, and ASH1L were identified as critical genes in the development of castration-resistant prostate cancer (CRPC), similar to mixed-lineage leukemia (MLL) complex family members. Knockdown of the SETD5 gene in 22Rv1 prostate carcinoma cells in vitro inhibited cancer cell growth and migration. CONCLUSIONS HMT gene variants may have a role in the pathogenesis of prostate cancer. Future studies may determine the role of HMT genes as prognostic biomarkers in patients with prostate cancer.

摘要

背景

组蛋白甲基转移酶（HMT）家族包括组蛋白赖氨酸甲基转移酶（HKMT）和组蛋白/蛋白质精氨酸甲基转移酶（PRMT）。HMT 基因变异在前列腺癌中的作用尚不清楚。因此，本研究旨在通过体外细胞研究和生物信息学分析，评估 HMT 基因变异在人类前列腺癌发病机制和预后中的作用。

材料和方法

基于癌症基因组图谱（TCGA）的数据集，对 51 个 HMT 基因在人前列腺癌中的表达进行了综合生物信息学分析。采用相关和回归分析确定前列腺癌中的关键 HMT。采用 Kaplan-Meier 和接受者操作特征曲线下面积（AUROC）评估 HMT 对预后的作用。研究了 22Rv1 人前列腺癌细胞的基因表达和功能。

结果

确定与前列腺癌发病机制有关的 HMT 基因包括 EZH2、SETD5、PRDM12、NSD1、SETD6、SMYD1 和 WHSC1L1 基因。EZH2、SETD5 和 SMYD1 基因被选为预后面板，SUV420H2 HMT 基因也被选为预后面板。SETD2、NSD1 和 ASH1L 被确定为去势抵抗性前列腺癌（CRPC）发展的关键基因，与混合谱系白血病（MLL）复合物家族成员相似。体外敲低 22Rv1 前列腺癌细胞中的 SETD5 基因可抑制癌细胞生长和迁移。

结论

HMT 基因变异可能在前列腺癌的发病机制中起作用。未来的研究可能会确定 HMT 基因作为前列腺癌患者预后生物标志物的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/13772f7bf644/medscimonit-25-193-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/8273732f1264/medscimonit-25-193-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/a45b84ae1164/medscimonit-25-193-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/3dcabff76280/medscimonit-25-193-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/bea57212973c/medscimonit-25-193-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/7fcd2559a675/medscimonit-25-193-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/138979beb181/medscimonit-25-193-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/8086519c6f71/medscimonit-25-193-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/13772f7bf644/medscimonit-25-193-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/8273732f1264/medscimonit-25-193-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/a45b84ae1164/medscimonit-25-193-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/3dcabff76280/medscimonit-25-193-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/bea57212973c/medscimonit-25-193-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/7fcd2559a675/medscimonit-25-193-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/138979beb181/medscimonit-25-193-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/8086519c6f71/medscimonit-25-193-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83b7/6330996/13772f7bf644/medscimonit-25-193-g008.jpg

相似文献

1
Integrated Analysis of Genetic Abnormalities of the Histone Lysine Methyltransferases in Prostate Cancer.前列腺癌中组蛋白赖氨酸甲基转移酶遗传异常的综合分析。
Med Sci Monit. 2019 Jan 7;25:193-239. doi: 10.12659/MSM.912294.
2
The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression.SRA 蛋白 UHRF1 促进表观遗传串扰，并参与前列腺癌的进展。
Oncogene. 2012 Nov 15;31(46):4878-87. doi: 10.1038/onc.2011.641. Epub 2012 Feb 13.
3
Tandem histone methyltransferase upregulation defines a unique aggressive prostate cancer phenotype.串联组蛋白甲基转移酶上调定义了独特的侵袭性前列腺癌表型。
Br J Cancer. 2021 Jul;125(2):247-254. doi: 10.1038/s41416-021-01398-7. Epub 2021 May 11.
4
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.PTIP与包含MLL3和MLL4的组蛋白H3赖氨酸4甲基转移酶复合物相关联。
J Biol Chem. 2007 Jul 13;282(28):20395-406. doi: 10.1074/jbc.M701574200. Epub 2007 May 11.
5
Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells.组蛋白H3赖氨酸9甲基转移酶G9a的下调诱导癌细胞中的中心体破坏和染色体不稳定。
PLoS One. 2008 Apr 30;3(4):e2037. doi: 10.1371/journal.pone.0002037.
6
Inactivation and Mutation Drive a Convergence toward Loss of Function of H3K36 Writers in Clear Cell Renal Cell Carcinomas.失活和突变促使透明细胞肾细胞癌中H3K36书写蛋白功能丧失趋同。
Cancer Res. 2017 Sep 15;77(18):4835-4845. doi: 10.1158/0008-5472.CAN-17-0143. Epub 2017 Jul 28.
7
Genetic alterations of histone lysine methyltransferases and their significance in breast cancer.组蛋白赖氨酸甲基转移酶的基因改变及其在乳腺癌中的意义。
Oncotarget. 2015 Feb 10;6(4):2466-82. doi: 10.18632/oncotarget.2967.
8
Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration.赖氨酸 207 和 325 由 SETD6 催化的 WDR5 甲基化促进乳腺癌细胞的增殖和迁移。
Oncol Rep. 2018 Nov;40(5):3069-3077. doi: 10.3892/or.2018.6669. Epub 2018 Aug 23.
9
Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function.核受体结合 SET 域蛋白 1（NSD1）甲基转移酶在协调组蛋白 H3 上赖氨酸 36 的甲基化与 RNA 聚合酶 II 功能中的作用。
Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16952-7. doi: 10.1073/pnas.1002653107. Epub 2010 Sep 13.
10
Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex.通过 MLL 组蛋白甲基转移酶复合物调控前列腺中染色质调节因子 EZH2 和 ANCCA/ATAD2 的发育和雄激素作用。
Prostate. 2013 Apr;73(5):455-66. doi: 10.1002/pros.22587. Epub 2012 Oct 4.

引用本文的文献

1
Structure and function of the lysine methyltransferase SETD2 in cancer: From histones to cytoskeleton.赖氨酸甲基转移酶SETD2在癌症中的结构与功能：从组蛋白到细胞骨架
Neoplasia. 2025 Jan;59:101090. doi: 10.1016/j.neo.2024.101090. Epub 2024 Nov 25.
2
SMYD family in cancer: epigenetic regulation and molecular mechanisms of cancer proliferation, metastasis, and drug resistance.癌症中的SMYD家族：癌症增殖、转移和耐药性的表观遗传调控及分子机制
Exp Mol Med. 2024 Nov;56(11):2325-2336. doi: 10.1038/s12276-024-01326-8. Epub 2024 Nov 1.
3
Genetic Alterations of in Solid Tumors Using Integrative Multi-Platform Analysis.

本文引用的文献

1
Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice.抑制胰腺癌中PRDM14的表达可抑制小鼠的癌症干细胞样特性和肝转移。
Carcinogenesis. 2017 Jun 1;38(6):638-648. doi: 10.1093/carcin/bgx040.
2
Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.Mll3和Mll4促进增强子RNA合成及启动子转录，且不依赖于H3K4单甲基化。
Mol Cell. 2017 May 18;66(4):568-576.e4. doi: 10.1016/j.molcel.2017.04.018. Epub 2017 May 5.
3
Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer.
采用整合式多平台分析方法研究实体瘤中的 基因突变。
Int J Mol Sci. 2024 May 31;25(11):6097. doi: 10.3390/ijms25116097.
4
SETD5 regulates the OGT-catalyzed O-GlcNAcylation of RNA polymerase II, which is involved in the stemness of colorectal cancer cells.SETD5 调控 OGT 催化的 RNA 聚合酶 II 的 O-GlcNAc 化，这一过程参与了结直肠癌细胞的干性。
Sci Rep. 2023 Nov 14;13(1):19885. doi: 10.1038/s41598-023-46923-1.
5
Alterations in the Epigenetic Machinery Associated with Prostate Cancer Health Disparities.与前列腺癌健康差异相关的表观遗传机制改变
Cancers (Basel). 2023 Jul 1;15(13):3462. doi: 10.3390/cancers15133462.
6
SETD2-H3K36ME3: an important bridge between the environment and tumors.SET结构域蛋白2-组蛋白H3赖氨酸36三甲基化：环境与肿瘤之间的重要桥梁
Front Genet. 2023 Jun 9;14:1204463. doi: 10.3389/fgene.2023.1204463. eCollection 2023.
7
Structure, activity and function of the lysine methyltransferase SETD5.赖氨酸甲基转移酶 SETD5 的结构、活性和功能。
Front Endocrinol (Lausanne). 2023 Feb 17;14:1089527. doi: 10.3389/fendo.2023.1089527. eCollection 2023.
8
Neurobehavioral characteristics of mice with mutations as models of IDD23 and KBG syndromes.具有作为IDD23和KBG综合征模型的突变的小鼠的神经行为特征。
Front Genet. 2023 Jan 4;13:1022339. doi: 10.3389/fgene.2022.1022339. eCollection 2022.
9
Histone lysine methylation patterns in prostate cancer microenvironment infiltration: Integrated bioinformatic analysis and histological validation.前列腺癌微环境浸润中的组蛋白赖氨酸甲基化模式：综合生物信息学分析与组织学验证
Front Oncol. 2022 Sep 28;12:981226. doi: 10.3389/fonc.2022.981226. eCollection 2022.
10
Structural insight into ASH1L PHD finger recognizing methylated histone H3K4 and promoting cell growth in prostate cancer.对ASH1L植物同源结构域（PHD）识别甲基化组蛋白H3K4并促进前列腺癌细胞生长的结构洞察。
Front Oncol. 2022 Aug 10;12:906807. doi: 10.3389/fonc.2022.906807. eCollection 2022.
通过创新的RNA干扰疗法沉默PRDM14表达可抑制乳腺癌的干性、致瘤性和转移。
Oncotarget. 2017 Jul 18;8(29):46856-46874. doi: 10.18632/oncotarget.16776.
4
Chromatin remodelling and DNA repair genes are frequently mutated in endometrioid endometrial carcinoma.染色质重塑和DNA修复基因在子宫内膜样子宫内膜癌中经常发生突变。
Int J Cancer. 2017 Apr 1;140(7):1551-1563. doi: 10.1002/ijc.30573. Epub 2017 Feb 2.
5
Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer.SF3B3 通过剪接 EZH2 前体 mRNA 促进肾癌的致瘤潜能。
Clin Cancer Res. 2017 Jul 1;23(13):3428-3441. doi: 10.1158/1078-0432.CCR-16-2020. Epub 2016 Nov 22.
6
Whole-exome sequencing identifies variants in invasive pituitary adenomas.全外显子组测序可识别侵袭性垂体腺瘤中的变异。
Oncol Lett. 2016 Oct;12(4):2319-2328. doi: 10.3892/ol.2016.5029. Epub 2016 Aug 16.
7
Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer.SETDB2组蛋白甲基转移酶在胃癌中的致癌作用
Oncotarget. 2016 Oct 11;7(41):67251-67265. doi: 10.18632/oncotarget.11625.
8
Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.组蛋白甲基转移酶KMT2C和KMT2D的表达降低与胰腺导管腺癌预后改善相关。
Cancer Res. 2016 Aug 15;76(16):4861-71. doi: 10.1158/0008-5472.CAN-16-0481. Epub 2016 Jun 8.
9
Translational and clinical implications of the genetic landscape of prostate cancer.前列腺癌基因图谱的转化及临床意义
Nat Rev Clin Oncol. 2016 Oct;13(10):597-610. doi: 10.1038/nrclinonc.2016.76. Epub 2016 Jun 1.
10
DNA methylation in PRDM8 is indicative for dyskeratosis congenita.PRDM8中的DNA甲基化是先天性角化不良的指征。
Oncotarget. 2016 Mar 8;7(10):10765-72. doi: 10.18632/oncotarget.7458.