儿童自闭症谱系障碍筛查：诊断准确性的荟萃分析。
Toddler Screening for Autism Spectrum Disorder: A Meta-Analysis of Diagnostic Accuracy.
机构信息
INICO-University of Salamanca, Pso. Canalejas, 169, 37008, Salamanca, Spain.
IBSAL-University of Salamanca, C/ Alfonso X El Sabio s/n, 37007, Salamanca, Spain.
出版信息
J Autism Dev Disord. 2019 May;49(5):1837-1852. doi: 10.1007/s10803-018-03865-2.
Great efforts focus on early detection of autism spectrum disorder, although some scientists and policy-makers have questioned early universal screening. The aim of this meta-analysis was to evaluate the diagnostic accuracy of the different screening tools. Several electronic databases were used to identify published studies. A Bayesian model was used to estimate the screening accuracy. The pooled sensitivity was 0.72 (95% CI 0.61-0.81), and the specificity was 0.98 (95% CI 0.97-0.99). Subgroup analyses to remove heterogeneity indicated sensitivity was 0.77 (95% CI 0.69-0.84), and specificity was 0.99 (95% CI 0.97-0.99; SD ≤ 0.01). Level 1 screening tools for ASD showed consistent statistically significant results and therefore are adequate to detect autism at 14-36 months.
尽管一些科学家和政策制定者对早期普遍筛查提出了质疑，但人们仍在努力早期发现自闭症谱系障碍。本荟萃分析旨在评估不同筛查工具的诊断准确性。使用多个电子数据库来确定已发表的研究。采用贝叶斯模型来估计筛查准确性。汇总的敏感度为 0.72（95%置信区间为 0.61-0.81），特异性为 0.98（95%置信区间为 0.97-0.99）。为消除异质性而进行的亚组分析表明，敏感度为 0.77（95%置信区间为 0.69-0.84），特异性为 0.99（95%置信区间为 0.97-0.99；SD≤0.01）。ASD 的一级筛查工具显示出一致的统计学显著结果，因此足以在 14-36 个月时检测自闭症。
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