Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Pathogenic Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China.
Tissue Eng Part A. 2019 Sep;25(17-18):1289-1299. doi: 10.1089/ten.TEA.2018.0255. Epub 2019 Mar 18.
The extracellular matrix (ECM)-inspired electrospinning scaffolds have a good cytocompatibility. Hyaluronic acid (HA) is one of the main components in the bladder ECM, but it is hard to be made by electrospinning alone. In this study, it is shown that coaxial electrospinning can fabricate poly(l-lactide)/poly(e-caprolactone) (PLCL)/HA nanofibers with the core-shell structure. The HA coating nanofibers have more hydrophilicity, which can promote cell proliferation and migration by filopodial outgrowth. We also fabricated domed PLCL/HA nanofiber scaffolds used in bladder regeneration by improving bladder capacity and facilitating smooth muscle proliferation.
受细胞外基质启发的电纺支架具有良好的细胞相容性。透明质酸（HA）是膀胱细胞外基质的主要成分之一，但单独用电纺法很难制备。本研究表明，同轴电纺可以制备具有核壳结构的聚（L-丙交酯）/聚（ε-己内酯）/HA 纳米纤维。HA 涂层纳米纤维具有更好的亲水性，通过丝状伪足的伸出促进细胞增殖和迁移。我们还通过改善膀胱容量和促进平滑肌增殖，制造了用于膀胱再生的穹顶状 PLCL/HA 纳米纤维支架。
