Gao Yujun, Wang Menglin, Yu RenQiang, Li Yaping, Yang Ying, Cui Xiangxiang, Zheng Jinou
Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Department of Otorhinolaryngology and Head and Neck Surgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Front Psychiatry. 2018 Dec 18;9:697. doi: 10.3389/fpsyt.2018.00697. eCollection 2018.
The default mode network (DMN) may be an important component involved in the broad-scale cognitive problems seen in patients with first-episode treatment-naive depression. Nevertheless, information is scarce regarding the changes in network homogeneity (NH) found in the DMN of these patients. Therefore, in this study, we explored the NH of the DMN in patients with first-episode treatment-naive depression. The study included 66 patients and 74 control participants matched by age, gender, educational level and health status who underwent resting-state functional magnetic resonance imaging (rs-fMRI) and the attentional network test (ANT). To assess data, the study utilizes NH and independent component analysis (ICA). Additionally, Spearman's rank correlation analysis is performed among significantly abnormal NH in depression patients and clinical measurements and executive control reaction time (ECRT). In comparison with the control group, patients with first-episode treatment-naive depression showed lower NH in the bilateral angular gyrus (AG), as well as increased NH in the bilateral precuneus (PCu) and posterior cingulate cortex (PCC). Likewise, patients with first-episode treatment-naive depression had longer ECRT. No significant relation was found between abnormal NH values and the measured clinical variables. Our results suggest patients with first-episode treatment-naive depression have abnormal NH values in the DMN. This highlights the significance of DMN in the pathophysiology of cognitive problems in depression. Our study also found alterations in executive functions in patients with first-episode treatment-naive depression.
默认模式网络（DMN）可能是初发未治疗抑郁症患者出现的广泛认知问题所涉及的一个重要组成部分。然而，关于这些患者DMN中网络同质性（NH）变化的信息却很匮乏。因此，在本研究中，我们探究了初发未治疗抑郁症患者DMN的NH。该研究纳入了66例患者和74名在年龄、性别、教育水平和健康状况方面相匹配的对照参与者，他们均接受了静息态功能磁共振成像（rs-fMRI）和注意力网络测试（ANT）。为评估数据，本研究采用了NH和独立成分分析（ICA）。此外，还对抑郁症患者中显著异常的NH与临床测量指标以及执行控制反应时间（ECRT）进行了Spearman等级相关分析。与对照组相比，初发未治疗抑郁症患者双侧角回（AG）的NH较低，而双侧楔前叶（PCu）和后扣带回皮质（PCC）的NH升高。同样，初发未治疗抑郁症患者的ECRT更长。在异常NH值与所测量的临床变量之间未发现显著相关性。我们的结果表明，初发未治疗抑郁症患者的DMN存在异常NH值。这凸显了DMN在抑郁症认知问题病理生理学中的重要性。我们的研究还发现初发未治疗抑郁症患者存在执行功能改变。
