Ma Ying Jie, Lee Bok Luel, Garred Peter
The Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
National Research Laboratory of Defense Proteins, College of Pharmacy, Pusan National University, Busan, Korea.
Exp Mol Med. 2017 Apr 21;49(4):e320. doi: 10.1038/emm.2017.51.
The complement system is an innate immune defense machinery comprising components that deploy rapid immune responses and provide efficient protection against foreign invaders and unwanted host elements. The complement system is activated upon recognition of pathogenic microorganisms or altered self-cells by exclusive pattern recognition molecules (PRMs), such as collectins, ficolins and pentraxins. Recent accumulating evidence shows that the different classes of effector PRMs build up a co-operative network and exert synergistic effects on complement activation. In this review, we describe our updated view of the crosstalk between previously unlinked PRMs in complement activation and the potential pathogenic effects during infection and inflammation.
补体系统是一种先天性免疫防御机制，由能够迅速展开免疫反应并有效抵御外来入侵者和有害宿主成分的组分构成。当通过诸如凝集素、纤维胶凝蛋白和五聚素等独特的模式识别分子（PRM）识别致病微生物或发生改变的自身细胞时，补体系统即被激活。最近越来越多的证据表明，不同类别的效应性PRM形成了一个合作网络，并在补体激活过程中发挥协同作用。在这篇综述中，我们阐述了对于补体激活过程中以前未关联的PRM之间的相互作用以及感染和炎症期间潜在致病效应的最新观点。
