Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Straße 4, Marburg, 35037, Germany.
Photochem Photobiol Sci. 2019 Feb 13;18(2):304-308. doi: 10.1039/c8pp00267c.
Photodynamic therapy is one of the most promising non-invasive strategies employed for the treatment of several kinds of bacterial infections. Though the vast majority of clinically approved photosensitisers are administered intravenously, most of the in vitro experiments are performed under static conditions which do not represent the physiological environment of the venous bloodstream. To address this issue, a dynamic circulation model was developed to facilitate in situ antibacterial photodynamic therapy under flow conditions to mimic blood stream infections.
光动力疗法是治疗多种细菌感染最有前途的非侵入性策略之一。虽然绝大多数临床批准的光敏剂都是通过静脉注射给药的，但大多数体外实验都是在静态条件下进行的，这些条件并不能代表静脉血流的生理环境。为了解决这个问题，开发了一种动态循环模型，以促进在流动条件下的原位抗菌光动力疗法，模拟血流感染。
