Department of Insect Physiology and Biochemistry, Institute for Biological Research "Siniša Stanković", University of Belgrade, Despot Stefan Blvd. 142, Belgrade, Serbia.
Environ Sci Pollut Res Int. 2019 Feb;26(6):6216-6222. doi: 10.1007/s11356-019-04133-1. Epub 2019 Jan 10.
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants which exert detrimental effects on living beings. Considering the health risk associated with exposure to these pollutants, their presence in food increases efforts to establish early-warning indicators of pollution. We aimed to examine the effects of environmentally relevant concentrations of fluoranthene (0.2 ng and 18 ng/g dry weight of diet) on the activities of midgut antioxidant and detoxification enzymes in Blaptica dubia. Significant changes of superoxide dismutase and catalase activities, recorded at the higher fluoranthene concentration regardless of the exposure time, suggest that they may be used as biomarkers of PAH pollution. Increased GST activity and decreased total GSH content, detected upon acute exposure to the lower concentration, indicate processes of detoxification. Reorganization of B. dubia mechanisms of defense in response to oxidative stress caused by exposure to dietary PAH point to the necessity for further examination of fluoranthene actions.
多环芳烃（PAHs）是普遍存在的环境污染物，对生物具有有害影响。考虑到接触这些污染物带来的健康风险，食品中存在这些污染物会增加建立污染预警指标的努力。我们旨在研究环境相关浓度的荧蒽（0.2ng 和 18ng/g 干重的饮食）对黄粉虫中肠抗氧化和解毒酶活性的影响。在较高的荧蒽浓度下，无论暴露时间如何，超氧化物歧化酶和过氧化氢酶活性的显著变化表明它们可能被用作 PAH 污染的生物标志物。在急性暴露于较低浓度时检测到的 GST 活性增加和总 GSH 含量减少表明存在解毒过程。黄粉虫防御机制对饮食中多环芳烃引起的氧化应激的重组表明有必要进一步研究荧蒽的作用。
