De Somer Filip, Bernolet Hendrik, Bouchez Stefaan, Bové Thierry
1 Laboratory for Experimental Cardiac Surgery, Ghent University, Belgium.
2 Department of Cardiac Surgery, University Hospital Ghent, Belgium.
Perfusion. 2019 May;34(4):318-322. doi: 10.1177/0267659118819927. Epub 2019 Jan 10.
This study evaluates the efficiency of emergency programs used by three contemporary cell washers. Both time necessary to process a given amount of blood and quality of the processed blood are investigated. The Fresenius Kabi Smart, Haemonetics Elite and LivaNova Xtra were validated using bovine blood, with a starting hematocrit of 13% or 21%. For all devices, the pre-programmed emergency program was used. The total volume processed in the 13% hematocrit group was 358 ± 68 mL for Fresenius, 375 ± 308 mL for Haemonetics and 497 ± 87 mL for LivaNova. In the 21% hematocrit group, the volumes were 533 ± 60 mL, 713 ± 142 mL and 798 ± 96 mL, respectively, showing a statistical difference between the Fresenius and LivaNova (p = 0.02). In the 13% hematocrit group, the Fresenius processed 45 ± 15 mL blood/min, the Haemonetics 62 ± 8 mL blood/min and the LivaNova 66 ± 1.5 mL blood/min. The difference between the Fresenius and LivaNova was statistically significant (p = 0.04). In the 21% hematocrit group, the processing speed was 69 ± 4 mL blood/min, 62 ± 8 mL blood/min and 77 ± 5 mL blood/min for the Fresenius, LivaNova and Haemonetics, respectively (p = 0.25). No major differences in the elimination of potassium, albumin and total protein or in hemolytic index were observed. No major differences were observed between discontinuous and continuous systems with respect to processing speed and wash quality with a starting hematocrit of 21%. Minor differences in processing speed were observed with a starting hematocrit of 13%.
本研究评估了三种当代细胞洗涤器所使用的应急程序的效率。研究了处理给定血量所需的时间以及处理后血液的质量。使用起始血细胞比容为13%或21%的牛血对费森尤斯卡比智能型、海莫奈蒂克斯精英型和利瓦诺瓦Xtra型进行了验证。对于所有设备，均使用预编程的应急程序。在血细胞比容为13%的组中，费森尤斯处理的总量为358±68 mL，海莫奈蒂克斯为375±308 mL，利瓦诺瓦为497±87 mL。在血细胞比容为21%的组中，处理量分别为533±60 mL、713±142 mL和798±96 mL，费森尤斯和利瓦诺瓦之间存在统计学差异（p = 0.02）。在血细胞比容为13%的组中，费森尤斯每分钟处理45±15 mL血液，海莫奈蒂克斯为62±8 mL血液/分钟，利瓦诺瓦为66±1.5 mL血液/分钟。费森尤斯和利瓦诺瓦之间的差异具有统计学意义（p = 0.04）。在血细胞比容为21%的组中，费森尤斯、利瓦诺瓦和海莫奈蒂克斯的处理速度分别为69±4 mL血液/分钟、62±8 mL血液/分钟和77±5 mL血液/分钟（p = 0.25）。在钾、白蛋白和总蛋白的清除或溶血指数方面未观察到重大差异。对于起始血细胞比容为21%的情况，在处理速度和洗涤质量方面，连续系统和非连续系统之间未观察到重大差异。对于起始血细胞比容为13%的情况，观察到了处理速度上的微小差异。
