Department of Neurossscience, BRAINlab, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
Faculty of Psychology, Department of Basic Psychological Research and Research Methods, University of Vienna, Liebiggasse 5, A-1010 Vienna, Austria; Faculty of Biosciences, Cell and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK.
Neurosci Biobehav Rev. 2019 May;100:129-165. doi: 10.1016/j.neubiorev.2018.12.016. Epub 2019 Jan 8.
Parkinson's disease (PD) is a devastating diagnosis with, however, potential for an extremely intriguing aesthetic component. Despite motor and cognitive deficits, an emerging collection of studies report a burst of visual artistic output and alterations in produced art in a subgroup of patients. This provides a unique window into the neurophysiological bases for why and how we might create and enjoy visual art, as well as into general brain function and the nature of PD or other neurodegenerative diseases. However, there has not been a comprehensive organization of literature on this topic. Nor has there been an attempt to connect case evidence and knowledge on PD with present understanding of visual art making in psychology and neuroaesthetics in order to propose hypotheses for documented artistic changes. Here, we collect the current research on this topic, tie this to PD symptoms and neurobiology, and provide new theories focusing on dopaminergic neuron damage, over-stimulation from dopamine agonist therapy, and context or genetic factors revealing the neurobiological basis of the visual artistic brain.
帕金森病（PD）是一种毁灭性的诊断，但具有非常有趣的美学成分的潜力。尽管存在运动和认知缺陷，但越来越多的研究报告指出，一小部分患者会出现视觉艺术创作的爆发和所创作艺术的变化。这为我们为什么以及如何创造和欣赏视觉艺术，以及为大脑功能和 PD 或其他神经退行性疾病的本质提供了一个独特的窗口。然而，目前还没有关于这个主题的文献的全面组织。也没有试图将 PD 病例证据和知识与心理学和神经美学中关于视觉艺术创作的现有理解联系起来，以提出对记录的艺术变化的假设。在这里，我们收集了关于这个主题的当前研究，将其与 PD 症状和神经生物学联系起来，并提供了新的理论，重点关注多巴胺能神经元损伤、多巴胺激动剂治疗的过度刺激，以及揭示视觉艺术大脑神经生物学基础的上下文或遗传因素。
