Department of Surgery, the Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.
Department of Clinical Laboratory, Pingshan District People's Hospital of Shenzhen, Shenzhen, Guangdong Province, China.
Biochim Biophys Acta Rev Cancer. 2019 Jan;1871(1):170-178. doi: 10.1016/j.bbcan.2018.12.004. Epub 2019 Jan 7.
FOXP3 is a transcription factor, which belongs to the family of FOX protein. FOXP3 was initially discovered in regulatory T cells and supposed to play a significant role in the process of regulatory T cell differentiation. Increasing evidence has shown that FOXP3 is also expressed in tumor cells. However, the results of tumor FOXP3 is inconsistent and even the opposite. In some types of human cancers, the expression of FOXP3 is upregulated, and it can promote the development of cancers, leading to a poor prognosis. While in some other types of cancers, it is a different story. The reason for the contradictory data is unknown. The discovery of FOXP3 isoforms, interaction between tumor cells and lymphocytes in the tumor microenvironment, subcellular location, and mutation of FOXP3 may provide some clues. In this review, we first summarize and analyze the recent development. The final section focuses on the regulation of FOXP3 expression.
叉头框蛋白 P3（FOXP3）是一种转录因子，属于叉头框蛋白家族。FOXP3 最初在调节性 T 细胞中被发现，被认为在调节性 T 细胞分化过程中发挥重要作用。越来越多的证据表明，FOXP3 也在肿瘤细胞中表达。然而，肿瘤 FOXP3 的结果并不一致，甚至相反。在某些类型的人类癌症中，FOXP3 的表达上调，它可以促进癌症的发展，导致预后不良。而在其他一些类型的癌症中则不然。造成这种矛盾数据的原因尚不清楚。FOXP3 异构体的发现、肿瘤微环境中肿瘤细胞与淋巴细胞的相互作用、FOXP3 的亚细胞定位和突变等可能提供了一些线索。在这篇综述中，我们首先总结和分析了最近的研究进展。最后一节重点关注 FOXP3 表达的调节。
