Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 400372 Cluj-Napoca, Romania. Faculty of Physics, Babeș-Bolyai University, 400084 Cluj-Napoca, Romania.
Biomed Mater. 2019 Feb 8;14(2):025011. doi: 10.1088/1748-605X/aafd7d.
The bioactive glasses can lead to the promotion of growth of granulation tissue, while the gold nanoparticles (AuNPs) can induce the acceleration of wound healing including tissue regeneration, connective tissue formation, and angiogenesis. The aim of this study was to evaluate the impact of using the bioactive glass (BG) and BG-AuNPs composites on skin wound healing in experimental rat models for 14 days. Sol-gel derived BGs and BG-AuNPs composites mixed with Vaseline at 6, 12 and 18 wt% were used to evaluate the repair response of the skin. During the process of healing, granulomatous reaction was observed in the wound treated with 12 and 18 wt% BG-Vaseline ointments. Furthermore, a strong vascular proliferation and complete wound regeneration were found in 18%BG-AuNPs-Vaseline treated groups. The results derived from the performed investigations revealed that the 18% BG-AuNPs-Vaseline ointment is a promising candidate for wound healing applications.
生物活性玻璃可以促进肉芽组织的生长，而金纳米粒子（AuNPs）可以诱导包括组织再生、结缔组织形成和血管生成在内的伤口愈合加速。本研究的目的是评估在实验大鼠模型中使用生物活性玻璃（BG）和 BG-AuNPs 复合材料对皮肤伤口愈合的影响，为期 14 天。使用溶胶-凝胶法制备的 BG 和 BG-AuNPs 复合材料与凡士林以 6、12 和 18wt%混合，以评估皮肤的修复反应。在愈合过程中，用 12 和 18wt%BG-凡士林软膏处理的伤口中观察到肉芽组织反应。此外，在 18%BG-AuNPs-凡士林处理组中发现了强烈的血管增殖和完全的伤口再生。从进行的研究中得出的结果表明，18%BG-AuNPs-凡士林软膏是一种有前途的伤口愈合应用候选物。
