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含硅酸盐玻璃和金纳米粒子的复合材料对皮肤创伤再生的影响。

The Impact of Composites with Silicate-Based Glasses and Gold Nanoparticles on Skin Wound Regeneration.

机构信息

Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 400372 Cluj-Napoca, Romania.

Faculty of Physics, Babeș-Bolyai University, 400084 Cluj-Napoca, Romania.

出版信息

Molecules. 2021 Jan 25;26(3):620. doi: 10.3390/molecules26030620.

DOI:10.3390/molecules26030620
PMID:33504095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7866013/
Abstract

The silver content of the skin regeneration ointments can influence its regeneration process but in the meantime, it can take the benefit of the antibacterial properties of silver by avoiding the bacterial infection of an open wound. In the current study, the skin healing and regeneration capacity of bioactive glass with spherical gold nanocages (BGAuIND) in the Vaseline ointments were evaluated in vivo comparing the bioactive glass (BG)-Vaseline and bioactive glass with spherical gold (BGAuSP)-Vaseline ointments. Spherical gold nanocages are stabilized with silver and as a consequence the BGAuIND exhibits great antibacterial activity. Histological examination of the cutaneous tissue performed on day 8 indicates a more advanced regeneration process in rats treated with BGAuSP-Vaseline. The histopathological examination also confirms the results obtained after 11 days post-intervention, when the skin is completely regenerated at rats treated with BGAuSP-Vaseline compared with the others groups where the healing was incomplete. This result is also confirmed by the macroscopic images of the evolution of wounds healing. As expected, the silver content influences the wound healing process but after two weeks, for all of the post-interventional trials from the groups of rats, the skin healing was completely.

摘要

皮肤再生软膏中的银含量可以影响其再生过程，但同时也可以利用银的抗菌特性，避免开放性伤口的细菌感染。在本研究中，通过比较含生物活性玻璃和球形金纳米笼的凡士林软膏（BGAuIND）、含生物活性玻璃的凡士林软膏（BG-Vaseline）和含球形金的凡士林软膏（BGAuSP-Vaseline），评估了载金纳米笼的生物活性玻璃（BGAuIND）在凡士林软膏中的皮肤愈合和再生能力。球形金纳米笼由银稳定，因此 BGAuIND 具有很强的抗菌活性。第 8 天对皮肤组织进行组织学检查表明，用 BGAuSP-Vaseline 治疗的大鼠的再生过程更为先进。组织病理学检查还证实了干预后 11 天的结果，与其他组相比，用 BGAuSP-Vaseline 治疗的大鼠的皮肤完全再生，而其他组的愈合不完全。伤口愈合的宏观图像也证实了这一结果。正如预期的那样，银含量会影响伤口愈合过程，但两周后，所有接受干预的大鼠组的皮肤都完全愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/d94afe39a65f/molecules-26-00620-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/6eaaf6fecfd2/molecules-26-00620-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/263751d69e87/molecules-26-00620-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/9c81a4e53b42/molecules-26-00620-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/aec5b3fabef9/molecules-26-00620-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/e9e8411c1f40/molecules-26-00620-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/8791a97ad6e3/molecules-26-00620-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/668b09578920/molecules-26-00620-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/d94afe39a65f/molecules-26-00620-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/0f7c85831b62/molecules-26-00620-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/137bfcd34fb4/molecules-26-00620-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/60504883707e/molecules-26-00620-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/9db6f7158510/molecules-26-00620-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/57c3f2a6cc69/molecules-26-00620-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/6eaaf6fecfd2/molecules-26-00620-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/263751d69e87/molecules-26-00620-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/9c81a4e53b42/molecules-26-00620-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/aec5b3fabef9/molecules-26-00620-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/e9e8411c1f40/molecules-26-00620-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/8791a97ad6e3/molecules-26-00620-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/668b09578920/molecules-26-00620-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9167/7866013/d94afe39a65f/molecules-26-00620-g013.jpg

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